Genome-wide screen for atopy susceptibility alleles in the Hutterites.

Ober C, Tsalenko A, Willadsen S, Newman D, Daniel R, Wu X, Andal J, Hoki D, Schneider D, True K, Schou C, Parry R, Cox N
Clin Exp Allergy. 1999 29 Suppl 4: 11-5

PMID: 10641559

A genome-wide screen for loci influencing positive skin prick tests (SPT) to airborne allergens was conducted in the Hutterites, a founder population of European ancestry. Positive SPT to 14 standardized allergens was measured in 370 subjects in our primary sample and 324 subjects in a replication sample. Evidence for linkage to positive SPT was assessed using the transmission disequilibrium test (TDT) with 337 autosomal markers (average spacing 9.13 cM, SD = 7.8 cM). Three loci showed the strongest overall evidence of linkage to atopy, with at least one allele-specific and a locus-specific p< 1 x 10(-4). This study provides evidence for at least three atopy-susceptibility loci in the Hutterites on chromosomes 1, 6 and 16.

MeSH Terms (15)

Adult Alleles Chromosome Mapping Ethnic Groups Europe European Continental Ancestry Group Female Founder Effect Genetic Linkage Genetic Predisposition to Disease Genome, Human Humans Hypersensitivity, Immediate Male Middle Aged

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