Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.

Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ
Proc Natl Acad Sci U S A. 2000 97 (2): 925-30

PMID: 10639181 · PMCID: PMC15432 · DOI:10.1073/pnas.97.2.925

MeSH Terms (26)

5,8,11,14-Eicosatetraynoic Acid Amides Animals Anti-Inflammatory Agents, Non-Steroidal Cell Line Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Drug Design Edema Esters Gastrointestinal Diseases Hindlimb Humans Indomethacin Isoenzymes Kinetics Macrophages Male Meclofenamic Acid Membrane Proteins Mice Prostaglandin-Endoperoxide Synthases Rats Rats, Sprague-Dawley Sheep

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