A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.

Jensen LH, Nitiss KC, Rose A, Dong J, Zhou J, Hu T, Osheroff N, Jensen PB, Sehested M, Nitiss JL
J Biol Chem. 2000 275 (3): 2137-46

PMID: 10636919 · DOI:10.1074/jbc.275.3.2137

MeSH Terms (18)

Alleles Antineoplastic Agents Cell Cycle DNA Topoisomerases, Type II Dose-Response Relationship, Drug Drug Resistance, Microbial Enzyme Inhibitors Genes, Dominant Humans Microbial Sensitivity Tests Mutagenesis Piperazines Protein Conformation Razoxane Saccharomyces cerevisiae Time Factors Topoisomerase II Inhibitors Ultracentrifugation

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