Multi-faceted regulation of gamma-glutamylcysteine synthetase.

Soltaninassab SR, Sekhar KR, Meredith MJ, Freeman ML
J Cell Physiol. 2000 182 (2): 163-70

PMID: 10623879 · DOI:10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1

Glutathione is an important antioxidant that is involved in numerous cellular activities. gamma-Glutamylcysteine synthetase (gammaGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of gammaGCS exhibit differential and coordinate transcription regulation. In addition, the subunits are regulated at the posttranscriptional and posttranslational levels. These various levels of regulation allow numerous stimuli to induce or inhibit activity.

Copyright 2000 Wiley-Liss, Inc.

MeSH Terms (12)

Amino Acid Sequence Animals Cell Physiological Phenomena Chromosome Mapping Disease Gene Expression Regulation Glutamate-Cysteine Ligase Glutathione Humans Isoenzymes Molecular Sequence Data Transcription, Genetic

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