A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3.

Pastey MK, Gower TL, Spearman PW, Crowe JE, Graham BS
Nat Med. 2000 6 (1): 35-40

PMID: 10613821 · PMCID: PMC7095870 · DOI:10.1038/71503

The fusion glycoproteins of human respiratory syncytial virus (RSV) and human parainfluenza virus type-3 (PIV-3) mediate virus entry and syncytium formation. Interaction between the fusion protein of RSV and RhoA, a small GTPase, facilitates virus-induced syncytium formation. We show here a RhoA-derived peptide inhibits RSV and syncytium formation induced by RSV and PIV-3, both in vitro by inhibition of cell-to-cell fusion and in vivo by reduction of peak titer by 2 log10 in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies.

MeSH Terms (16)

Amino Acid Sequence Animals Cell Fusion Cells, Cultured Enzyme-Linked Immunosorbent Assay Giant Cells Humans Mice Mice, Inbred BALB C Molecular Sequence Data Parainfluenza Virus 3, Human Peptide Fragments Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections rhoA GTP-Binding Protein Vaccinia virus

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