Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries.

Anderson VE, Zaniewski RP, Kaczmarek FS, Gootz TD, Osheroff N
J Biol Chem. 1999 274 (50): 35927-32

PMID: 10585479 · DOI:10.1074/jbc.274.50.35927

MeSH Terms (14)

Anti-Infective Agents Biological Evolution Ciprofloxacin DNA Damage DNA Repair DNA Topoisomerase IV DNA Topoisomerases, Type II Escherichia coli Etoposide Fluoroquinolones Gram-Positive Bacteria Kinetics Quinolones Staphylococcus aureus

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