DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement.

Byl JA, Fortune JM, Burden DA, Nitiss JL, Utsugi T, Yamada Y, Osheroff N
Biochemistry. 1999 38 (47): 15573-9

PMID: 10569941 · DOI:10.1021/bi991791o

MeSH Terms (17)

Aminoquinolines Antigens, Neoplasm Antineoplastic Agents DNA, Fungal DNA-Binding Proteins DNA Damage DNA Topoisomerases, Type I DNA Topoisomerases, Type II Etoposide Humans Hydrolysis Indenes Isoenzymes Plasmids Saccharomyces cerevisiae Topoisomerase II Inhibitors Topoisomerase I Inhibitors

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