NMR-based discovery of phosphotyrosine mimetics that bind to the Lck SH2 domain.

Hajduk PJ, Zhou MM, Fesik SW
Bioorg Med Chem Lett. 1999 9 (16): 2403-6

PMID: 10476877 · DOI:10.1016/s0960-894x(99)00403-5

Using an NMR-based screen, a series of novel phosphotyrosine mimetics were discovered that bind to the SH2 domain of Lck. These compounds may serve as useful leads for the design of nonpeptide inhibitors of SH2 domains with improved bioavailability and metabolic stability compared to the natural ligands that contain phosphotyrosine.

MeSH Terms (7)

Magnetic Resonance Spectroscopy Molecular Mimicry Molecular Structure Phosphotyrosine Protein-Tyrosine Kinases Protein Binding src Homology Domains

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