Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD).

Backstrom JR, Chang MS, Chu H, Niswender CM, Sanders-Bush E
Neuropsychopharmacology. 1999 21 (2 Suppl): 77S-81S

PMID: 10432492 · DOI:10.1016/S0893-133X(99)00005-6

For more than 40 years the hallucinogen lysergic acid diethylamide (LSD) has been known to modify serotonin neurotransmission. With the advent of molecular and cellular techniques, we are beginning to understand the complexity of LSD's actions at the serotonin 5-HT2 family of receptors. Here, we discuss evidence that signaling of LSD at 5-HT2C receptors differs from the endogenous agonist serotonin. In addition, RNA editing of the 5-HT2C receptor dramatically alters the ability of LSD to stimulate phosphatidylinositol signaling. These findings provide a unique opportunity to understand the mechanism(s) of partial agonism.

MeSH Terms (18)

3T3 Cells Amino Acid Sequence Animals Base Sequence Humans Lysergic Acid Diethylamide Mice Phosphatidylinositols Rats Receptor, Serotonin, 5-HT2C Receptors, Serotonin Recombinant Proteins RNA Editing Sequence Alignment Serotonin Serotonin Receptor Agonists Signal Transduction Transfection

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