Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K
Chem Res Toxicol. 1999 12 (7): 623-9

PMID: 10409402 · DOI:10.1021/tx990028s

MeSH Terms (16)

Animals Aryl Hydrocarbon Hydroxylases Benzo(a)pyrene Carcinogens Chromatography, High Pressure Liquid Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System Dihydroxydihydrobenzopyrenes Epoxide Hydrolases Humans Liver Mutagenicity Tests Rabbits Rats Recombinant Proteins Salmonella typhimurium

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