NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus.

Miyata T, Maeda T, Lee JE
Genes Dev. 1999 13 (13): 1647-52

PMID: 10398678 · PMCID: PMC316850 · DOI:10.1101/gad.13.13.1647

NeuroD, a bHLH transcription factor, is implicated in differentiation of neurons and pancreatic beta cells. NeuroD-null mice die shortly after birth due to severe neonatal diabetes. To examine if there is postnatal neuronal phenotype in these mice, we rescued them from neonatal lethality by introducing a transgene encoding the mouse neuroD gene under the insulin promoter. These mice survive to adulthood but display severe neurological phenotype due to neuronal deficit in the granule layers of the cerebellum and hippocampus. We show here that NeuroD is required for these postnatally generated microneurons to undergo proper differentiation, the absence of which results in cell death.

MeSH Terms (20)

Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors Cell Count Cell Differentiation Cerebellum Genetic Therapy Hippocampus In Situ Nick-End Labeling Insulin Mice Mice, Knockout Mice, Neurologic Mutants Mice, Transgenic Nerve Tissue Proteins Neurons Phenotype Promoter Regions, Genetic Recombinant Fusion Proteins Transgenes

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