Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.

Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS, Wiley HS, Coffey RJ
Br J Cancer. 1999 80 (7): 1012-9

PMID: 10362109 · PMCID: PMC2363033 · DOI:10.1038/sj.bjc.6690456

MeSH Terms (19)

Amphiregulin Antibodies, Monoclonal Antineoplastic Agents Autocrine Communication Caco-2 Cells Cell Division Cell Polarity Colonic Neoplasms DNA DNA Replication EGF Family of Proteins ErbB Receptors Glycoproteins Growth Substances Humans Intercellular Signaling Peptides and Proteins RNA, Messenger Transforming Growth Factor alpha Tumor Cells, Cultured

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