Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies.

Linton MF, Fazio S
Curr Opin Lipidol. 1999 10 (2): 97-105

PMID: 10327277 · DOI:10.1097/00041433-199904000-00003

The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.

MeSH Terms (12)

Animals Aorta Apolipoproteins E Arteriosclerosis Bone Marrow Transplantation Foam Cells Leukocytes Lipoproteins Macrophages Mice Models, Biological Receptors, LDL

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