Postoperative pelvic irradiation in early stage uterine mixed mullerian tumors.

Molpus KL, Redlin-Frazier S, Reed G, Burnett LS, Jones HW
Eur J Gynaecol Oncol. 1998 19 (6): 541-6

PMID: 10215437

PURPOSE OF INVESTIGATION - To review our management experience with uterine mixed mullerian tumors (MMTs) in order to evaluate potential prognostic indicators, and assess the efficacy of various treatment modalities.

METHODS - A retrospective, clinicopathologic evaluation of 43 patients presenting for treatment of uterine MMTs between 1982 and 1992 was conducted. Diagnostic criteria for inclusion was the presence of both a malignant glandular or squamous epithelial component, and a homologous or heterologous stromal component.

RESULTS - Overall 2- and 5-year cancer related Kaplan-Meier survival estimates with 95% confidence intervals were 44 (.28, .59) and 26% [.12, .39], respectively. Survivals were 83 [.62, .99] and 58% [.31, .85] when disease was confined to the uterus, and 22 [.03, .41] and 7% [.01, .20] when disease extended beyond the uterus. Clinical staging was often inaccurate, with 29% of clinical stage I or II disease being upstaged at laparotomy. A significant survival advantage was found in patients with stage I or II disease treated with surgery plus pelvic irradiation (p = 0.001), as compared to those treated with surgery alone. The prognosis after disease recurrence was poor, irrespective of secondary therapy, with a median survival of 11 months.

CONCLUSIONS - A therapeutic advantage may be gained from postoperative pelvic irradiation in the treatment of surgical stage I or II uterine MMT.

MeSH Terms (17)

Adult Aged Aged, 80 and over Confidence Intervals Disease-Free Survival Female Humans Laparotomy Middle Aged Mixed Tumor, Mullerian Neoplasm Staging Pelvis Prognosis Radiotherapy, Adjuvant Retrospective Studies Survival Rate Uterine Neoplasms

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