Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR
Pharm Res. 1999 16 (3): 408-14

PMID: 10213372 · DOI:10.1023/a:1018877803319

MeSH Terms (17)

Animals Aryl Hydrocarbon Hydroxylases ATP Binding Cassette Transporter, Subfamily B, Member 1 Biological Transport Caco-2 Cells Cells, Cultured Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Drug Resistance, Multiple Enzyme Inhibitors Humans Male Mice Oxidoreductases, N-Demethylating Pharmacokinetics Substrate Specificity

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