Regulating the onset of mitosis.

Ohi R, Gould KL
Curr Opin Cell Biol. 1999 11 (2): 267-73

PMID: 10209160

In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.

MeSH Terms (24)

Animals Biological Transport CDC2 Protein Kinase Cell Compartmentation Cell Cycle Cyclin B DNA Damage Drosophila Proteins Eukaryotic Cells Fungal Proteins Fungi G2 Phase Humans Maturation-Promoting Factor Mitosis Models, Biological Phosphorylation Protein-Serine-Threonine Kinases Protein-Tyrosine Kinases Protein Isoforms Protein Processing, Post-Translational Spindle Apparatus Vertebrates Xenopus laevis

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