Melatonin suppression by illumination of upper and lower visual fields.

Lasko TA, Kripke DF, Elliot JA
J Biol Rhythms. 1999 14 (2): 122-5

PMID: 10194648 · DOI:10.1177/074873099129000506

As a guide to optimizing the geometry of bright light treatment, 12 healthy subjects were studied three times in the laboratory from 11 p.m. to 2 a.m. On three evenings, in counterbalanced orders, subjects received 500 lux in the upper visual field, 500 lux in the lower visual field, or 5 lux while watching television. In the upper visual field, 500 lux significantly suppressed melatonin, as compared to 500 lux in the lower visual field or to 5 lux. In the lower visual field, 500 lux produced intermediate suppression of borderline significance. The results suggest that bright light treatment of depression or circadian phase disorders might be most effective when applied in the upper visual field.

MeSH Terms (14)

Adult Circadian Rhythm Female Humans Light Male Matched-Pair Analysis Melatonin Photic Stimulation Saliva Statistics, Nonparametric Television Time Factors Visual Fields

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