The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.

Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nishimura T
J Exp Med. 1999 189 (7): 1121-8

PMID: 10190903 · PMCID: PMC2193012 · DOI:10.1084/jem.189.7.1121

MeSH Terms (20)

Adjuvants, Immunologic Animals Cytotoxicity, Immunologic Dendritic Cells Drug Synergism Galactosylceramides Gene Expression Regulation Immunity, Cellular Interferon-gamma Interleukin-12 Killer Cells, Natural Ligands Lymphocyte Activation Lymphocyte Subsets Mice Mice, Inbred C57BL Mice, Knockout Receptors, Interleukin Receptors, Interleukin-12 Up-Regulation

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