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Mutational analysis of the vacA promoter provides insight into gene transcription in Helicobacter pylori.

Forsyth MH, Cover TL
J Bacteriol. 1999 181 (7): 2261-6

PMID: 10094707 · PMCID: PMC93642

Analysis of 12 Helicobacter pylori promoters indicates the existence of a consensus -10 hexamer (TAtaaT) but little conservation of -35 sequences. In this study, mutations in either the H. pylori vacA -10 region or the -35 region resulted in decreased vacA transcription and suggested that an extended -10 motif is utilized. Thus, despite the lack of a -35 consensus sequence for H. pylori promoters, the -35 region plays a functional role in vacA transcription.

MeSH Terms (15)

Amino Acid Sequence Bacterial Proteins Bacterial Toxins Base Sequence Consensus Sequence DNA, Bacterial DNA-Directed RNA Polymerases Gene Expression Regulation, Bacterial Genes, Bacterial Helicobacter pylori Molecular Sequence Data Mutagenesis Promoter Regions, Genetic Sigma Factor Transcription, Genetic

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