Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.

Brown CB, Boyer AS, Runyan RB, Barnett JV
Science. 1999 283 (5410): 2080-2

PMID: 10092230 · DOI:10.1126/science.283.5410.2080

Transforming growth factor-beta (TGF-beta) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-beta signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-beta2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling.

MeSH Terms (21)

Animals Cell Movement Chick Embryo Culture Techniques Endocardium Endothelium Genetic Vectors Heart Heart Atria Heart Ventricles Immune Sera Ligands Mesoderm Myocardium Protein-Serine-Threonine Kinases Proteoglycans Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta Retroviridae Signal Transduction Transforming Growth Factor beta

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