Functional design in the actin cytoskeleton.

Small JV, Rottner K, Kaverina I
Curr Opin Cell Biol. 1999 11 (1): 54-60

PMID: 10047522 · DOI:10.1016/s0955-0674(99)80007-6

Changes in cell shape, anchorage and motility are all associated with the dynamic reorganisation of the architectural arrays of actin filaments that make up the actin cytoskeleton. The relative expression of these functionally different actin filament arrays is intimately linked to the pattern of contacts that a cell develops with its extracellular substrate. Cell polarity is acquired by the development of an asymmetric pattern of substrate contacts, effected in a specific, site-directed manner by the delivery of adhesion-site modulators along microtubules.

MeSH Terms (18)

Actins Animals Biological Transport Cell Adhesion Cell Line Cell Movement Cell Polarity Cell Size Cytoskeleton Dyneins GTP-Binding Proteins Kinesin Membrane Proteins Microtubules Models, Biological Myosins rac GTP-Binding Proteins rhoB GTP-Binding Protein

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