Increased CSF F2-isoprostane concentration in probable AD.

Montine TJ, Beal MF, Cudkowicz ME, O'Donnell H, Margolin RA, McFarland L, Bachrach AF, Zackert WE, Roberts LJ, Morrow JD
Neurology. 1999 52 (3): 562-5

PMID: 10025788 · DOI:10.1212/wnl.52.3.562

OBJECTIVE - To quantify F2-isoprostane levels in CSF obtained from the lumbar cistern of patients with AD, ALS, and controls.

BACKGROUND - Studies of human postmortem tissue and experimental models have suggested a role for oxidative damage in the pathogenesis of several neurodegenerative diseases, especially AD and ALS. F2-isoprostanes are exclusive products of free-radical-mediated peroxidation of arachidonic acid that have been widely used as quantitative biomarkers of lipid peroxidation in vivo in humans. Recently, we showed that F2-isoprostane concentrations are significantly elevated in CSF obtained postmortem from the lateral ventricles of patients with definite AD compared with controls.

METHODS - F2-isoprostanes were quantified by gas chromatography/negative ion chemical ionization mass spectrometry.

RESULTS - CSF F2-isoprostanes were increased significantly in patients with probable AD, but not in ALS patients, compared with controls.

CONCLUSIONS - Increased CSF F2-isoprostanes are not an inevitable consequence of neurodegeneration and suggest that increased brain oxidative damage may occur early in the course of AD.

MeSH Terms (8)

Aged Alzheimer Disease Amyotrophic Lateral Sclerosis Dinoprost Female Humans Linear Models Male

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