Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Kulkarni RN, BrĂ¼ning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR
Cell. 1999 96 (3): 329-39

PMID: 10025399 · DOI:10.1016/s0092-8674(00)80546-2

MeSH Terms (20)

Alleles Animals Blood Glucose Diabetes Mellitus, Type 2 Humans Immunohistochemistry Insulin Insulin Secretion Integrases Islets of Langerhans Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Organ Specificity Pancreas Rats Receptor, Insulin Transgenes Viral Proteins

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