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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 811 to 820 of 832

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Apoptosis and the prognostic significance of p53 mutation.
Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE
(1994) Cold Spring Harb Symp Quant Biol 59: 419-26
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Drug Resistance, Genes, p53, Humans, Mice, Mice, Nude, Mutation, Neoplasms, Experimental, Prognosis
Added May 29, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor.
Kleinerman DI, Troncoso P, Lin SH, Pisters LL, Sherwood ER, Brooks T, von Eschenbach AC, Hsieh JT
(1995) Cancer Res 55: 1215-20
MeSH Terms: Antineoplastic Agents, Cell Adhesion Molecules, Epithelium, Homeostasis, Humans, Male, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms
Show Abstract · Added October 18, 2015
Cell adhesion molecules have been suggested to function as tumor suppressor molecules. We have been studying one of the epithelial cell adhesion molecules (C-CAM), which belongs to the immunoglobulin gene superfamily. Transfection of a C-CAM cDNA expression vector into a highly tumorigenic human prostate cancer cell line (PC-3) suppresses tumor formation in nude mice. Alternatively, reducing C-CAM expression levels in the nontumorigenic rat prostate epithelial cell line NbE by the antisense expression vector markedly increases tumorigenicity of NbE cells in nude mice. These results suggest that C-CAM may be a tumor suppressor in prostate cancer. In this study, we examined the relationship between C-CAM expression during human prostate development and neoplastic progression by immunohistochemical staining of frozen sections. C-CAM predominantly localized on the plasma membrane of the basal cell layer in both the fetal and normal adult prostate gland. However, an overall decreased staining was seen in benign prostatic hyperplasia and high grade prostatic intraepithelial neoplasia. Furthermore, C-CAM was not detected in prostate carcinomas. Thus, a decrease in C-CAM expression may be an early event in hyperplastic/neoplastic transformation. These observations support the suggestion that C-CAM is a tumor suppressor in prostate cancer progression.
0 Communities
1 Members
0 Resources
9 MeSH Terms
A phase II trial of piroxantrone in disseminated malignant melanoma. A Southwest Oncology Group study.
Sosman JA, Flaherty LE, Liu PY, Fletcher W, Thompson JA, Hantel A, Sondak V
(1995) Invest New Drugs 13: 83-7
MeSH Terms: Adult, Aged, Anthraquinones, Antineoplastic Agents, Evaluation Studies as Topic, Female, Humans, Male, Melanoma, Middle Aged, Pyrazoles
Show Abstract · Added March 5, 2014
Piroxantrone is one of the anthrapyrazoles developed in an effort to combine the broad antitumor activity of the anthracyclines with decreased myocardial toxicity. It has shown activity in metastatic melanoma during phase I trials. The Southwest Oncology Group (SWOG) conducted a phase II trial in disseminated malignant melanoma with piroxantrone administered at 150 mg/m2 intravenously over 1 h every 21 days, based upon the phase I experience. Forty-six eligible patients were registered to the trial and 44 were evaluable for response. Two partial responses, Wayne of 6 and 9 months duration were observed for an overall response rate of 5% (95% confidence interval 1%-15%). Thirty-six of 46 eligible patients have died with an estimated median survival of 5 months (95% confidence interval 3-8 months). Toxicities were tolerable with granulocytopenia being the predominant toxicity. Based upon the observed response rate, it is concluded that piroxantrone administered at this dose and schedule has detectable but minimal activity, and does not warrant further investigation in this disease.
0 Communities
1 Members
0 Resources
11 MeSH Terms
Clinical experience with malignant pheochromocytomas.
Scott HW, Reynolds V, Green N, Page D, Oates JA, Robertson D, Roberts S
(1982) Surg Gynecol Obstet 154: 801-18
MeSH Terms: Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Antineoplastic Agents, Catecholamines, Child, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Pheochromocytoma, Retrospective Studies
Show Abstract · Added December 10, 2013
In a 30 year period at Vanderbilt University Hospital, the affiliated Nashville General Hospital and the Nashville Veterans Administration Hospital, 64 patients with pheochromocytoma have been observed. In eight of these, the tumor proved to be malignant. Retrospective review of biologic characteristics of pheochromocytomas in this series included clinical, diagnostic imaging, chemical and histopathologic data. Aside from presence of distant metastases, none of these features had predictive value in indicating the biologic malignant nature of the primary tumor. One patient has been cured by radical surgical resection for 16 years. Three others have died with metastatic tumor and three patients are alive with metastatic tumor.
0 Communities
2 Members
0 Resources
14 MeSH Terms
Conditionability of cancer chemotherapy patients.
Ingle RJ, Burish TG, Wallston KA
(1984) Oncol Nurs Forum 11: 97-102
MeSH Terms: Adult, Aged, Antineoplastic Agents, Conditioning, Classical, Female, Humans, Male, Middle Aged, Nausea, Vomiting
Added July 28, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Meningeal carcinomatosis: diagnosis, treatment, and nursing care.
Wujcik D
(1983) Oncol Nurs Forum 10: 35-40
MeSH Terms: Antineoplastic Agents, Carcinoma, Female, Humans, Meningeal Neoplasms, Patient Care Planning, Tomography, X-Ray Computed
Added March 27, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
Kingsnorth AN, Russell WE, McCann PP, Diekema KA, Malt RA
(1983) Cancer Res 43: 4035-8
MeSH Terms: Adenocarcinoma, Antineoplastic Agents, Cell Cycle, Cell Line, Cell Survival, Eflornithine, Fluorouracil, Humans, Kinetics, Ornithine, Putrescine, Spermidine
Show Abstract · Added December 10, 2013
Because alpha-difluoromethylornithine (DFMO) reduces the incidence of experimental colon cancers, inhibits the growth of human lung cancer cells and human leukemia cells in culture, and in combination with methylglyoxal (bis)guanylhydrazone induces remission in children with leukemia, its effectiveness against a human colon adenocarcinoma cell line (Colo 205) was tested alone and in combination with 5-fluorouracil (5-FU). Both DFMO (2 X 10(-4) M) and 5-FU (10(-6) M) inhibited Colo 205 cell proliferation. Above 5 X 10(-4) M DFMO (p less than 0.001) and at 10(-4) M 5-FU (p less than 0.001), Colo 205 growth was completely inhibited. Although DFMO did not sensitize Colo 205 cells to a noninhibitory concentration of 5-FU, the effectiveness of inhibitory concentrations of 5-FU and DFMO in reducing Colo 205 cell growth was additive. DFMO (2 X 10(-4) M) caused 89 to 93% inhibition of ornithine decarboxylase activity (p less than 0.001) and reduced levels of putrescine (93%; p less than 0.01) and spermidine (57%; p less than 0.02). Growth rate and the intracellular putrescine and spermidine contents were restored by 10(-6) M putrescine. DFMO could be an effective chemotherapeutic agent against human colonic cancer because of its effects at such unusually low concentrations in vitro.
0 Communities
1 Members
0 Resources
12 MeSH Terms
Randomized vs. historical clinical trials. Are the benefits worth the cost?
Dupont WD
(1985) Am J Epidemiol 122: 940-6
MeSH Terms: Antineoplastic Agents, Clinical Trials as Topic, Double-Blind Method, Evaluation Studies as Topic, Female, Humans, Male, Neoplasms, Prognosis, Random Allocation
Added March 21, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Chemotherapy administration.
Wujcik D
(1987) Cancer Nurs 10: 53-64
MeSH Terms: Antineoplastic Agents, Humans, Infusions, Parenteral, Neoplasms, Oncology Nursing, Programmed Instruction as Topic
Added March 27, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.
Guengerich FP
(1988) Cancer Res 48: 2946-54
MeSH Terms: Animals, Antineoplastic Agents, Biotransformation, Carcinogens, Cytochrome P-450 Enzyme System, Humans, Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms