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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 61 to 65 of 65

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Crystal structure of a conformation-selective casein kinase-1 inhibitor.
Mashhoon N, DeMaggio AJ, Tereshko V, Bergmeier SC, Egli M, Hoekstra MF, Kuret J
(2000) J Biol Chem 275: 20052-60
MeSH Terms: Casein Kinases, Computer Simulation, Crystallography, X-Ray, Enzyme Inhibitors, Humans, Hydrogen Bonding, Indoles, Inhibitory Concentration 50, Kinetics, Models, Molecular, Molecular Sequence Data, Mutation, Oxindoles, Peptide Library, Phloroglucinol, Phosphotransferases, Protein Binding, Protein Conformation, Protein Isoforms, Protein Kinase Inhibitors, Protein Structure, Tertiary, Schizosaccharomyces, Static Electricity
Added June 26, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
Chun YJ, Kim MY, Guengerich FP
(1999) Biochem Biophys Res Commun 262: 20-4
MeSH Terms: Cell Membrane, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Escherichia coli, Gene Expression, Humans, Inhibitory Concentration 50, Kinetics, Microsomes, Liver, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Oxidoreductases, Resveratrol, Stilbenes
Added May 26, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.
Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL
(1999) Yeast 15: 755-63
MeSH Terms: Antifungal Agents, Binding Sites, Candida albicans, Carbon Monoxide, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Formates, Humans, Inhibitory Concentration 50, Itraconazole, Ketoconazole, Kinetics, Ligands, Oxidoreductases, Recombinant Proteins, Spectrum Analysis, Sterol 14-Demethylase, Titrimetry
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy.
Ohmori T, Yang JL, Price JO, Arteaga CL
(1998) Exp Cell Res 245: 350-9
MeSH Terms: Antineoplastic Agents, Breast Neoplasms, CDC2-CDC28 Kinases, Cell Aggregation, Cell Cycle, Cell Cycle Proteins, Cell Death, Cisplatin, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinases, Cyclins, DNA Fragmentation, Gene Expression Regulation, Neoplastic, Humans, Immunoglobulin G, Inhibitory Concentration 50, Microtubule-Associated Proteins, Phosphorylation, Protein Serine-Threonine Kinases, Proteins, Retinoblastoma Protein, Transforming Growth Factor beta, Tumor Cells, Cultured, Tumor Suppressor Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.
Kalgutkar AS, Kozak KR, Crews BC, Hochgesang GP, Marnett LJ
(1998) J Med Chem 41: 4800-18
MeSH Terms: Acetylation, Acetylene, Alkynes, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Agents, Colonic Neoplasms, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Dinoprostone, Exudates and Transudates, Humans, In Vitro Techniques, Inhibitory Concentration 50, Isoenzymes, Kinetics, Macrophages, Membrane Proteins, Mice, Prostaglandin-Endoperoxide Synthases, Rats, Sheep, Structure-Activity Relationship, Sulfides, Thromboxane B2, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms