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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 61 to 70 of 74

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW
(2005) Nature 436: 807-11
MeSH Terms: Adoptive Transfer, Alleles, Animals, Apoptosis, Apoptosis Regulatory Proteins, Bcl-2-Like Protein 11, Burkitt Lymphoma, Carrier Proteins, Cell Cycle Proteins, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Genes, myc, Humans, Membrane Proteins, Mice, Mice, Inbred C57BL, Mutation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-myc, Stem Cell Transplantation, Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p53
Added March 10, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW
(2004) J Med Chem 47: 4417-26
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Breast Neoplasms, Carrier Proteins, Caspases, Cell Division, Cell Line, Tumor, Humans, Intracellular Signaling Peptides and Proteins, Ligands, Mice, Mitochondrial Proteins, Peptide Fragments, Protein Structure, Tertiary, Proteins, Structure-Activity Relationship, Transplantation, Heterologous, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Death, destruction, and the proteasome.
Tansey WP
(2004) N Engl J Med 351: 393-4
MeSH Terms: Apoptosis, Apoptosis Regulatory Proteins, Carrier Proteins, Caspases, High-Temperature Requirement A Serine Peptidase 2, Humans, Intracellular Signaling Peptides and Proteins, Mitochondrial Proteins, Peptide Hydrolases, Proteasome Endopeptidase Complex, Serine Endopeptidases, Ubiquitin
Added March 10, 2014
0 Communities
1 Members
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12 MeSH Terms
CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer.
Gutiérrez MI, Siraj AK, Khaled H, Koon N, El-Rifai W, Bhatia K
(2004) Mod Pathol 17: 1268-74
MeSH Terms: Acid Anhydride Hydrolases, Adenomatous Polyposis Coli Protein, Apoptosis Regulatory Proteins, Cadherins, Calcium-Calmodulin-Dependent Protein Kinases, Carcinoma, Squamous Cell, Cell Cycle Proteins, CpG Islands, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, DNA Methylation, DNA-Binding Proteins, Death-Associated Protein Kinases, Genes, Tumor Suppressor, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Isoenzymes, Neoplasm Proteins, Nuclear Proteins, O(6)-Methylguanine-DNA Methyltransferase, Polymerase Chain Reaction, Receptors, Retinoic Acid, Schistosomiasis haematobia, Tumor Protein p73, Tumor Suppressor Protein p14ARF, Tumor Suppressor Proteins, Urinary Bladder Neoplasms
Added March 5, 2014
0 Communities
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28 MeSH Terms
Structural biology of the Bcl-2 family of proteins.
Petros AM, Olejniczak ET, Fesik SW
(2004) Biochim Biophys Acta 1644: 83-94
MeSH Terms: Amino Acid Sequence, Apoptosis Regulatory Proteins, BH3 Interacting Domain Death Agonist Protein, Carrier Proteins, Membrane Proteins, Models, Molecular, Molecular Sequence Data, Oncogene Proteins, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Sequence Alignment, Viral Proteins, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, bcl-Associated Death Protein, bcl-X Protein
Added March 5, 2014
0 Communities
1 Members
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17 MeSH Terms
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.
Weber T, Lu M, Andera L, Lahm H, Gellert N, Fariss MW, Korinek V, Sattler W, Ucker DS, Terman A, Schröder A, Erl W, Brunk UT, Coffey RJ, Weber C, Neuzil J
(2002) Clin Cancer Res 8: 863-9
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Caspases, Colonic Neoplasms, Colony-Forming Units Assay, Cyclin-Dependent Kinase Inhibitor p21, Cyclins, Drug Synergism, Humans, Membrane Glycoproteins, Mice, Myocardial Contraction, Myocardium, Neoplasm Invasiveness, TNF-Related Apoptosis-Inducing Ligand, Tocopherols, Transfection, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Tumor Suppressor Protein p53, Vitamin E, Xenograft Model Antitumor Assays, alpha-Tocopherol
Added August 12, 2010
1 Communities
1 Members
0 Resources
25 MeSH Terms
Structural biology. Controlling the caspases.
Fesik SW, Shi Y
(2001) Science 294: 1477-8
MeSH Terms: Amino Acid Motifs, Animals, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Carrier Proteins, Caspase Inhibitors, Caspases, Crystallography, X-Ray, Cysteine Proteinase Inhibitors, Dimerization, Humans, Hydrogen Bonding, Intracellular Signaling Peptides and Proteins, Mitochondria, Mitochondrial Proteins, Protein Structure, Secondary, Protein Structure, Tertiary, Proteins, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
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20 MeSH Terms
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M
(2001) Nat Struct Biol 8: 899-907
MeSH Terms: Adenosine Triphosphate, Amino Acid Sequence, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinases, Catalytic Domain, Crystallography, X-Ray, Death-Associated Protein Kinases, Humans, Models, Molecular, Molecular Sequence Data, Neoplasms, Protein Conformation, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Solvents, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.
Velentza AV, Schumacher AM, Weiss C, Egli M, Watterson DM
(2001) J Biol Chem 276: 38956-65
MeSH Terms: Amino Acid Sequence, Animals, Apoptosis, Apoptosis Regulatory Proteins, Binding Sites, Blotting, Western, Brain, Calcium-Calmodulin-Dependent Protein Kinases, Catalysis, Catalytic Domain, Cattle, DNA, Complementary, Death-Associated Protein Kinases, Electrophoresis, Polyacrylamide Gel, Humans, Kinetics, Models, Molecular, Molecular Sequence Data, Mutagenesis, Mutagenesis, Site-Directed, Open Reading Frames, Peptide Library, Peptides, Phosphorylation, Protein Binding, Protein Structure, Tertiary, Recombinant Proteins, Sequence Homology, Amino Acid, Substrate Specificity, Tumor Suppressor Proteins
Added May 27, 2014
0 Communities
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30 MeSH Terms
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
(2000) Nature 408: 1004-8
MeSH Terms: Amino Acid Sequence, Antineoplastic Agents, Apoptosis Regulatory Proteins, Binding Sites, Carrier Proteins, Caspase 9, Caspase Inhibitors, Cloning, Molecular, Cysteine Proteinase Inhibitors, Escherichia coli, Humans, Intracellular Signaling Peptides and Proteins, Magnetic Resonance Spectroscopy, Mitochondrial Proteins, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Protein Binding, Protein Structure, Tertiary, Proteins, Sequence Homology, Amino Acid, Structure-Activity Relationship, X-Linked Inhibitor of Apoptosis Protein
Added March 5, 2014
0 Communities
1 Members
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23 MeSH Terms