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Results: 51 to 53 of 53

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Chromosome 19 translocation, overexpression of Notch3, and human lung cancer.
Dang TP, Gazdar AF, Virmani AK, Sepetavec T, Hande KR, Minna JD, Roberts JR, Carbone DP
(2000) J Natl Cancer Inst 92: 1355-7
MeSH Terms: Adult, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Chromosome Mapping, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 19, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Karyotyping, Lung Neoplasms, Mesothelioma, Proto-Oncogene Proteins, RNA, Messenger, Receptor, Notch3, Receptors, Cell Surface, Receptors, Notch, Translocation, Genetic, Tumor Cells, Cultured, Up-Regulation
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.
Huppert SS, Jacobsen TL, Muskavitch MA
(1997) Development 124: 3283-91
MeSH Terms: Animals, Animals, Genetically Modified, Drosophila, Drosophila Proteins, Feedback, Gene Expression Regulation, Developmental, Genes, Insect, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Metamorphosis, Biological, Phenotype, Pupa, Receptors, Notch, Signal Transduction, Wings, Animal
Show Abstract · Added January 11, 2011
Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis. We find that partitioning of these fates is dependent on Delta-mediated signalling from 22 to 30 hours after puparium formation at 25 degrees C. Within the provein, Delta is expressed more highly in central provein cells (presumptive vein cells) and Notch is expressed more highly in lateral provein cells (presumptive intervein cells). Accumulation of Notch in presumptive intervein cells is dependent on Delta signalling activity in presumptive vein cells and constitutive Notch receptor activity represses Delta accumulation in presumptive vein cells. When Delta protein expression is elevated ectopically in presumptive intervein cells, complementary Delta and Notch expression patterns in provein cells are reversed, and vein loss occurs because central provein cells are unable to stably adopt the vein cell fate. Our findings imply that Delta-Notch signalling exerts feedback regulation on Delta and Notch expression during metamorphic wing vein development, and that the resultant asymmetries in Delta and Notch expression underlie the proper specification of vein and intervein cell fates within the provein.
1 Communities
1 Members
0 Resources
15 MeSH Terms
Notch1 is required for the coordinate segmentation of somites.
Conlon RA, Reaume AG, Rossant J
(1995) Development 121: 1533-45
MeSH Terms: Animals, Apoptosis, Embryonic Induction, Gene Expression, Genotype, Immunohistochemistry, In Situ Hybridization, Membrane Proteins, Mesoderm, Mice, Mice, Transgenic, Models, Genetic, Molecular Sequence Data, Morphogenesis, Mutagenesis, Site-Directed, Phenotype, Receptors, Notch
Show Abstract · Added January 20, 2011
Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of neurogenesis, myogenesis or apoptosis. We conclude that Notch1 function is not essential for these processes, at least in early postimplantation development. However, we have found that somitogenesis is delayed and disorganized in Notch1 mutant embryos. We propose that Notch1 normally coordinates the process of somitogenesis, and we provide a model of how this might occur.
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17 MeSH Terms