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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 51 to 60 of 61

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
Yun CH, Okerholm RA, Guengerich FP
(1993) Drug Metab Dispos 21: 403-9
MeSH Terms: Contraceptives, Oral, Cytochrome P-450 CYP2E1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Humans, Hydroxylation, In Vitro Techniques, Microsomes, Liver, Mixed Function Oxygenases, NADP, Norpregnenes, Oxidation-Reduction, Stereoisomerism, Terfenadine
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Perilla ketone increases endothelial cell monolayer permeability in vitro.
Waters CM, Alexander JS, Harris TR, Haselton FR
(1993) J Appl Physiol (1985) 74: 2493-501
MeSH Terms: Actins, Animals, Aorta, Thoracic, Blotting, Western, Cattle, Cell Membrane Permeability, Cytochrome P-450 Enzyme Inhibitors, Cytoskeleton, Electrophoresis, Polyacrylamide Gel, Endothelium, Vascular, Female, Ketoconazole, Microscopy, Fluorescence, Monoterpenes, Pregnancy, Sheep, Sodium Fluoride, Staining and Labeling, Terpenes
Added May 27, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule.
Burns KD, Capdevila J, Wei S, Breyer MD, Homma T, Harris RC
(1995) Am J Physiol 269: C831-40
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Calcium, Cells, Cultured, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Cytosol, Epidermal Growth Factor, Female, Inositol Phosphates, Kidney Tubules, Proximal, Mitosis, Osmolar Concentration, Oxygenases, Rabbits, Signal Transduction
Added August 19, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.
Guengerich FP
(1988) Mol Pharmacol 33: 500-8
MeSH Terms: Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Ethinyl Estradiol, Humans, Immunologic Techniques, In Vitro Techniques, Microsomes, Liver, Nifedipine, Oxidation-Reduction, Substrate Specificity, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR
(1988) Arch Biochem Biophys 261: 257-63
MeSH Terms: 5,8,11,14-Eicosatetraynoic Acid, Animals, Arachidonate Lipoxygenases, Arachidonic Acid, Arachidonic Acids, Aspirin, Clotrimazole, Cyclooxygenase Inhibitors, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Indomethacin, Ketoconazole, Male, Masoprocol, Microsomes, Liver, NADP, Oxygenases, Rats, Rats, Inbred Strains
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation.
Bondon A, Macdonald TL, Harris TM, Guengerich FP
(1989) J Biol Chem 264: 1988-97
MeSH Terms: Animals, Benzylamines, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Gas Chromatography-Mass Spectrometry, Magnetic Resonance Spectroscopy, Male, Microsomes, Liver, Molecular Structure, Rats, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Brian WR, Srivastava PK, Umbenhauer DR, Lloyd RS, Guengerich FP
(1989) Biochemistry 28: 4993-9
MeSH Terms: Catalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, DNA, Electrophoresis, Gene Expression Regulation, Genetic Vectors, Hexobarbital, Humans, Liver, Mephenytoin, Mixed Function Oxygenases, Oxidation-Reduction, Plasmids, Saccharomyces cerevisiae, Spectrophotometry, Ultraviolet, Sulfaphenazole, Tolbutamide
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs.
Guengerich FP
(1990) Am J Obstet Gynecol 163: 2159-63
MeSH Terms: Animals, Contraceptives, Oral, Hormonal, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme Inhibitors, Ethinyl Estradiol, Humans, Hydroxylation, Norpregnenes, Progestins, Steroid Hydroxylases, Steroids
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene.
Guengerich FP
(1990) Chem Res Toxicol 3: 363-71
MeSH Terms: Contraceptives, Oral, Cytochrome P-450 Enzyme Inhibitors, Ethinyl Estradiol, Humans, Hydroxylation, Microsomes, Liver, Nifedipine, Norpregnenes, Oxidation-Reduction, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
Guengerich FP, Kim DH, Iwasaki M
(1991) Chem Res Toxicol 4: 168-79
MeSH Terms: Acrylonitrile, Animals, Antibodies, Benzene, Carcinogens, Cytochrome P-450 CYP2E1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Ditiocarb, Humans, Hydrocarbons, Chlorinated, Kinetics, Microsomes, Liver, Molecular Weight, Oxidation-Reduction, Oxidoreductases, N-Demethylating, Rats, Styrene, Styrenes, Urethane, Vinyl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms