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Results: 41 to 48 of 48

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Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.
Elsea SH, McGuirk PR, Gootz TD, Moynihan M, Osheroff N
(1993) Antimicrob Agents Chemother 37: 2179-86
MeSH Terms: Animals, Anti-Infective Agents, CHO Cells, Cattle, Cell Death, Cells, Cultured, Cricetinae, DNA, Fluoroquinolones, Humans, Nucleic Acid Conformation, Quinolones, Structure-Activity Relationship, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential.
Corbett AH, Guerry P, Pflieger P, Osheroff N
(1993) Antimicrob Agents Chemother 37: 2599-605
MeSH Terms: 4-Quinolones, Animals, Anti-Infective Agents, Benzimidazoles, DNA Topoisomerases, Type II, DNA, Bacterial, Drosophila melanogaster, Nucleic Acid Conformation, Pyrimidines, Pyrimidinones, Stimulation, Chemical
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
Osheroff N, Corbett AH, Elsea SH, Westergaard M
(1994) Cancer Chemother Pharmacol 34 Suppl: S19-25
MeSH Terms: Amsacrine, Animals, Anti-Infective Agents, Antineoplastic Agents, DNA, DNA Damage, DNA Topoisomerases, Type II, Etoposide, Fluoroquinolones, Genistein, Humans, Isoflavones, Models, Structural, Quinolones, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
Elsea SH, Hsiung Y, Nitiss JL, Osheroff N
(1995) J Biol Chem 270: 1913-20
MeSH Terms: Amino Acid Sequence, Animals, Anti-Infective Agents, DNA Topoisomerases, Type II, Drug Resistance, Ellipticines, Fluoroquinolones, Histidine, Humans, Kinetics, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, Point Mutation, Quinolones, Recombinant Proteins, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Topoisomerase II Inhibitors, Tyrosine
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
Hsiung Y, Elsea SH, Osheroff N, Nitiss JL
(1995) J Biol Chem 270: 20359-64
MeSH Terms: Anti-Infective Agents, Base Sequence, DNA Topoisomerases, Type II, Drug Resistance, Microbial, Escherichia coli, Etoposide, Fluoroquinolones, Genes, Bacterial, Genes, Fungal, Kinetics, Macromolecular Substances, Molecular Sequence Data, Mutagenesis, Site-Directed, Oligodeoxyribonucleotides, Point Mutation, Quinolones, Recombinant Proteins, Saccharomyces cerevisiae, Serine, Species Specificity, Tryptophan
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Moynihan M, Sutcliffe JA, Osheroff N
(1991) J Biol Chem 266: 14585-92
MeSH Terms: Animals, Anti-Infective Agents, Catalysis, Cell Line, Cell Survival, Cricetinae, Cricetulus, DNA, DNA Topoisomerases, Type II, Drosophila melanogaster, Electrophoresis, Agar Gel, Etoposide, Fluoroquinolones, Hydrolysis, Molecular Structure, Quinolones
Added February 20, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group.
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N
(1992) Antimicrob Agents Chemother 36: 751-6
MeSH Terms: Animals, Anti-Infective Agents, CHO Cells, Cricetinae, DNA, DNA Topoisomerases, Type II, Dose-Response Relationship, Drug, Drosophila melanogaster, Electrophoresis, Agar Gel, Fluoroquinolones, In Vitro Techniques, Quinolones
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.
Elsea SH, Osheroff N, Nitiss JL
(1992) J Biol Chem 267: 13150-3
MeSH Terms: Anti-Infective Agents, Cell Survival, DNA Damage, DNA Topoisomerases, Type II, Fluoroquinolones, Mutation, Quinolones, Saccharomyces cerevisiae, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms