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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 41 to 50 of 53

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Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
McCubrey JA, Sokolosky ML, Lehmann BD, Taylor JR, Navolanic PM, Chappell WH, Abrams SL, Stadelman KM, Wong EW, Misaghian N, Horn S, Bäsecke J, Libra M, Stivala F, Ligresti G, Tafuri A, Milella M, Zarzycki M, Dzugaj A, Chiarini F, Evangelisti C, Martelli AM, Terrian DM, Franklin RA, Steelman LS
(2008) Adv Enzyme Regul 48: 113-35
MeSH Terms: Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Breast Neoplasms, Cell Cycle, Cell Transformation, Neoplastic, Cellular Senescence, Doxorubicin, Drug Resistance, Neoplasm, Extracellular Signal-Regulated MAP Kinases, Female, Humans, Metabolic Networks and Pathways, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Protein Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Tumor Cells, Cultured, raf Kinases
Added January 20, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Steelman LS, Navolanic PM, Sokolosky ML, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman KM, Terrian DM, Leslie NR, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA
(2008) Oncogene 27: 4086-95
MeSH Terms: Amino Acid Substitution, Antibiotics, Antineoplastic, Breast Neoplasms, Cell Line, Tumor, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Female, Gene Expression, Humans, Mutation, Missense, PTEN Phosphohydrolase, Protein Kinases, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases, Transfection
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.
Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D
(2008) Proc Natl Acad Sci U S A 105: 2521-6
MeSH Terms: Adenocarcinoma, Aging, Alleles, Animals, Cell Shape, Disease Models, Animal, Epithelium, Exons, Gene Deletion, Gene Expression Regulation, Neoplastic, Male, Mice, Mice, Transgenic, Neoplasm Invasiveness, PTEN Phosphohydrolase, Prostatic Neoplasms, Recombinant Proteins
Added February 25, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages.
Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M
(2007) J Immunol 179: 8350-6
MeSH Terms: Animals, Dinoprostone, Female, Guanine Nucleotide Exchange Factors, Klebsiella pneumoniae, Macrophages, Alveolar, PTEN Phosphohydrolase, Phagocytosis, Phosphatidylinositol 3-Kinases, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Proto-Oncogene Proteins c-akt, Rats, Rats, Wistar, Receptors, IgG, Tyrosine
Added May 4, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.
Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L
(2007) Mol Cell Biol 27: 8098-112
MeSH Terms: Animals, Catalysis, Cell Differentiation, Cell Proliferation, Cell Survival, HeLa Cells, Humans, Inositol Polyphosphate 5-Phosphatases, Insulin, Mice, Mutant Proteins, Myoblasts, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol Phosphates, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Phosphoric Monoester Hydrolases, Phosphorylation, Protein Structure, Tertiary, Proto-Oncogene Proteins c-akt, Rats, Serum
Added December 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin.
Shao J, Washington MK, Saxena R, Sheng H
(2007) Carcinogenesis 28: 2476-83
MeSH Terms: Adenocarcinoma, Adenoma, Adenomatous Polyposis Coli, Animals, Apoptosis, Cell Line, Transformed, Cell Survival, Colonic Neoplasms, Crosses, Genetic, Genes, ras, Heterozygote, Intestinal Mucosa, Mice, Mice, Transgenic, Mutation, Neoplasm Invasiveness, Osteopontin, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Signal Transduction
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A
(2006) Cancer Res 66: 3375-80
MeSH Terms: Animals, Carcinoma, Endometrioid, Cell Transformation, Neoplastic, Endometrial Neoplasms, Estrogen Receptor alpha, Female, Mice, Mice, Inbred C57BL, PTEN Phosphohydrolase, Phosphorylation, Proto-Oncogene Proteins c-akt
Added June 14, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
(2006) Mol Cell Biol 26: 2772-81
MeSH Terms: Animals, Cell Death, Cell Proliferation, Diabetes Mellitus, Experimental, Drug Resistance, Gene Deletion, Glucose, Homeostasis, Insulin-Secreting Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Mutant Strains, Organ Size, Oxidative Stress, PTEN Phosphohydrolase, Streptozocin
Added February 23, 2011
1 Communities
1 Members
0 Resources
17 MeSH Terms
Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway.
Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart CG
(2005) J Neuropathol Exp Neurol 64: 341-9
MeSH Terms: Adolescent, Adult, Cerebellar Neoplasms, Female, Ganglioneuroma, Hamartoma Syndrome, Multiple, Humans, Immunohistochemistry, Male, Middle Aged, PTEN Phosphohydrolase, Phosphoric Monoester Hydrolases, Protein Kinases, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Thyroid Diseases, Tumor Suppressor Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
[PTEN expression and its significance in human primary hepatocellular carcinoma].
Wan XW, Wang HY, Jiang M, He YQ, Liu SQ, Cao HF, Qiu XH, Tang L, Wu MC
(2003) Zhonghua Gan Zang Bing Za Zhi 11: 490-2
MeSH Terms: Adult, Biomarkers, Tumor, Carcinoma, Hepatocellular, Female, Humans, Liver Neoplasms, Male, Middle Aged, PTEN Phosphohydrolase, Phosphoric Monoester Hydrolases, RNA, Messenger, RNA, Neoplasm, Tumor Suppressor Proteins
Added February 25, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms