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Differences in response in vivo to amphotericin B among Candida albicans strains.
O'Day DM, Ray WA, Robinson RD, Head WS, Williams TE
(1991) Invest Ophthalmol Vis Sci 32: 1569-72
MeSH Terms: Administration, Topical, Amphotericin B, Animals, Candida albicans, Candidiasis, Colony Count, Microbial, Cornea, Dose-Response Relationship, Drug, Drug Resistance, Microbial, Eye Infections, Fungal, Humans, Keratitis, Rabbits
Show Abstract · Added March 5, 2014
A group of ten Candida albicans strains previously determined to be resistant or susceptible to topical amphotericin B in vivo and in vitro were exposed to treatment with different concentrations of the drug in a quantitative model of candidal keratitis in Dutch-belted rabbits. After 5 days of topical treatment with amphotericin B eye drops in concentrations of 0.3%, 0.03%, or 0.003%, quantitative isolate recovery in treated animals was compared with that of untreated controls. A dose response was observed for all five susceptible strains. The two strains that were most sensitive to amphotericin B in vitro also were the most susceptible in vivo. At each dose level there was a two- to eightfold reduction in isolate recovery among highly susceptible strains compared with less susceptible strains (P less than 0.05). The five resistant strains remained so even when the 0.3% concentration was used. Among strains of C. albicans susceptible to amphotericin B, there appeared to be a variation in degree of susceptibility in vivo that correlated with the minimum inhibitory concentration.
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