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A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.
Izzo AA, Izzo LS, Kasimos J, Majka S
(2004) Tuberculosis (Edinb) 84: 387-96
MeSH Terms: Animals, Colony Count, Microbial, Cytokines, Drug Administration Schedule, Female, Granuloma, Leukocyte Count, Lung, Matrix Metalloproteinase Inhibitors, Mice, Mice, Inbred C57BL, Phenylalanine, Thiophenes, Tuberculosis, Pulmonary
Added August 4, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.
Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S, Goldstein DJ
(2004) Arthritis Rheum 50: 2974-84
MeSH Terms: Comorbidity, Depressive Disorder, Major, Double-Blind Method, Duloxetine Hydrochloride, Female, Fibromyalgia, Humans, Male, Middle Aged, Neurotransmitter Uptake Inhibitors, Sex Factors, Thiophenes, Treatment Outcome
Added September 18, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles.
Vincent S, Bieck PR, Garland EM, Loghin C, Bymaster FP, Black BK, Gonzales C, Potter WZ, Robertson D
(2004) Circulation 109: 3202-7
MeSH Terms: Adolescent, Adrenergic Uptake Inhibitors, Adult, Dose-Response Relationship, Drug, Duloxetine Hydrochloride, Female, Heart Rate, Humans, Male, Methoxyhydroxyphenylglycol, Norepinephrine, Norepinephrine Plasma Membrane Transport Proteins, Posture, Radioligand Assay, Sensitivity and Specificity, Symporters, Systole, Thiophenes, Tyramine
Added December 10, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz.
Navamal M, McGrath C, Stewart J, Blans P, Villamena F, Zweier J, Fishbein JC
(2002) J Org Chem 67: 9406-13
MeSH Terms: Algorithms, Anticarcinogenic Agents, Chromatography, High Pressure Liquid, Electron Spin Resonance Spectroscopy, Free Radicals, Glutathione, Kinetics, Models, Molecular, Molecular Structure, Pyrazines, Sulfhydryl Compounds, Thiones, Thiophenes
Added January 27, 2012
0 Communities
1 Members
0 Resources
13 MeSH Terms
Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells.
Chen JK, Capdevila J, Harris RC
(2002) Proc Natl Acad Sci U S A 99: 6029-34
MeSH Terms: Animals, COS Cells, Cell Line, Cloning, Molecular, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme System, DNA, Epidermal Growth Factor, Epithelial Cells, Heparin-binding EGF-like Growth Factor, Humans, Intercellular Signaling Peptides and Proteins, Ligands, Models, Biological, Muscle, Smooth, Oxygenases, Phenylalanine, Phosphorylation, Precipitin Tests, Protein Binding, Signal Transduction, Swine, Thiophenes, Transcriptional Activation, U937 Cells
Added August 19, 2013
1 Communities
1 Members
0 Resources
25 MeSH Terms
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP
(2000) Chem Res Toxicol 13: 245-52
MeSH Terms: Anticarcinogenic Agents, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Humans, Isothiocyanates, Pyrazines, Quinolines, Sulfoxides, Thiocyanates, Thiones, Thiophenes
Added May 26, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
New drugs on the horizon: matrix metalloproteinase inhibitors.
Rothenberg ML, Nelson AR, Hande KR
(1999) Stem Cells 17: 237-40
MeSH Terms: Antineoplastic Agents, Azepines, Biphenyl Compounds, Humans, Hydroxamic Acids, Metalloendopeptidases, Organic Chemicals, Phenylalanine, Phenylbutyrates, Protease Inhibitors, Pyrazines, Sulfonamides, Thiophenes
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
Goss KJ, Brown PD, Matrisian LM
(1998) Int J Cancer 78: 629-35
MeSH Terms: Animals, Antineoplastic Agents, Intestinal Neoplasms, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Transgenic, Phenylalanine, Protease Inhibitors, Rats, Thiophenes, Tissue Inhibitor of Metalloproteinase-1
Added August 13, 2010
1 Communities
0 Members
0 Resources
12 MeSH Terms
Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor.
Dempsey PJ, Meise KS, Yoshitake Y, Nishikawa K, Coffey RJ
(1997) J Cell Biol 138: 747-58
MeSH Terms: Animals, Biological Transport, Cell Line, Cell Membrane, Cell Polarity, Dogs, Epidermal Growth Factor, Extracellular Space, Humans, Hydrolysis, Kidney, Metalloendopeptidases, Molecular Weight, Phenylalanine, Protein Precursors, Protein Processing, Post-Translational, Protein Structure, Tertiary, Solubility, Thiophenes
Added March 27, 2014
1 Communities
1 Members
0 Resources
19 MeSH Terms
Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V
(1997) Science 277: 225-8
MeSH Terms: Animals, Breast, Cell Adhesion, Cell Adhesion Molecules, Cell Division, Cell Line, Cell Movement, Cell Size, Collagenases, Epithelial Cells, Epithelium, Extracellular Matrix, Female, Fibrinolysin, Gelatinases, Humans, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Metalloendopeptidases, Mice, Phenylalanine, Protease Inhibitors, Rats, Recombinant Fusion Proteins, Skin Neoplasms, Thiophenes
Added March 27, 2014
1 Communities
1 Members
0 Resources
26 MeSH Terms