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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 31 to 40 of 47

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Critical role of gap junction coupled KATP channel activity for regulated insulin secretion.
Rocheleau JV, Remedi MS, Granada B, Head WS, Koster JC, Nichols CG, Piston DW
(2006) PLoS Biol 4: e26
MeSH Terms: Animals, Calcium, Cations, Divalent, Cells, Cultured, Gap Junctions, Glucose, Insulin, Insulin Secretion, Islets of Langerhans, Membrane Potentials, Models, Biological, Potassium Channels, Potassium Channels, Inwardly Rectifying, Tissue Culture Techniques
Added August 22, 2011
1 Communities
0 Members
0 Resources
14 MeSH Terms
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I
(2006) J Biol Chem 281: 5246-57
MeSH Terms: ATP-Binding Cassette Transporters, Adenosine Triphosphate, Animals, Arginine, Blood Glucose, Blotting, Western, Calcium, Cytosol, Exons, Female, Genotype, Glucose, Hepatocyte Nuclear Factor 4, Heterozygote, Immunohistochemistry, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Fluorescence, Models, Genetic, Multidrug Resistance-Associated Proteins, Patch-Clamp Techniques, Polymerase Chain Reaction, Potassium, Potassium Channels, Inwardly Rectifying, Potassium Chloride, RNA, Messenger, Receptors, Drug, Reverse Transcriptase Polymerase Chain Reaction, Sulfonylurea Compounds, Sulfonylurea Receptors, Tissue Distribution, Transgenes
Added February 23, 2011
1 Communities
1 Members
0 Resources
38 MeSH Terms
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor.
Shiota C, Rocheleau JV, Shiota M, Piston DW, Magnuson MA
(2005) Am J Physiol Endocrinol Metab 289: E570-7
MeSH Terms: ATP-Binding Cassette Transporters, Animals, Cells, Cultured, Female, Glucagon, Glucose, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Multidrug Resistance-Associated Proteins, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Sulfonylurea Receptors
Added December 10, 2013
1 Communities
3 Members
1 Resources
15 MeSH Terms
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH
(2005) Biochem Biophys Res Commun 330: 1073-9
MeSH Terms: AMP-Activated Protein Kinases, ATP-Binding Cassette Transporters, Adenosine Triphosphate, Aminoimidazole Carboxamide, Animals, Calcium, Drug Synergism, Enzyme Activation, Glucose, In Vitro Techniques, Insulin, Insulin Secretion, Islets of Langerhans, Mice, Mice, Inbred C57BL, Mice, Knockout, Multidrug Resistance-Associated Proteins, Multienzyme Complexes, Potassium Channels, Potassium Channels, Inwardly Rectifying, Protein Serine-Threonine Kinases, Receptors, Drug, Ribonucleosides, Sulfonylurea Receptors
Added February 23, 2011
1 Communities
1 Members
0 Resources
24 MeSH Terms
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM
(2004) Am J Physiol Endocrinol Metab 286: E834-43
MeSH Terms: 1-Methyl-3-isobutylxanthine, ATP-Binding Cassette Transporters, Acetylcholine, Animals, Blood Glucose, Calcium, Glucagon, Glucagon-Like Peptide 1, In Vitro Techniques, Insulin, Insulin Secretion, Intracellular Fluid, Islets of Langerhans, Membrane Potentials, Mice, Mice, Inbred Strains, Mice, Knockout, Multidrug Resistance-Associated Proteins, Peptide Fragments, Phosphodiesterase Inhibitors, Potassium Channels, Inwardly Rectifying, Protein Precursors, Receptors, Drug, Second Messenger Systems, Signal Transduction, Sulfonylurea Receptors
Added February 23, 2011
1 Communities
1 Members
1 Resources
26 MeSH Terms
Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics.
Gumina RJ, Pucar D, Bast P, Hodgson DM, Kurtz CE, Dzeja PP, Miki T, Seino S, Terzic A
(2003) Am J Physiol Heart Circ Physiol 284: H2106-13
MeSH Terms: Adenosine Triphosphate, Animals, Energy Metabolism, Heart, In Vitro Techniques, Ischemic Preconditioning, Myocardial, Magnetic Resonance Spectroscopy, Mice, Mice, Knockout, Myocardial Ischemia, Myocardium, Phosphocreatine, Potassium Channels, Inwardly Rectifying, Sarcolemma
Added February 21, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Kir6.2 is required for adaptation to stress.
Zingman LV, Hodgson DM, Bast PH, Kane GC, Perez-Terzic C, Gumina RJ, Pucar D, Bienengraeber M, Dzeja PP, Miki T, Seino S, Alekseev AE, Terzic A
(2002) Proc Natl Acad Sci U S A 99: 13278-83
MeSH Terms: Adaptation, Biological, Animals, Arrhythmias, Cardiac, Calcium, Death, Sudden, Electrophysiology, Hemodynamics, Homeostasis, Ions, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardium, Neurons, Perfusion, Physical Conditioning, Animal, Physical Exertion, Potassium Channels, Inwardly Rectifying, Stress, Physiological, Time Factors
Added February 21, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA
(2002) J Biol Chem 277: 37176-83
MeSH Terms: ATP-Binding Cassette Transporters, Animals, Blood Glucose, Carbachol, Cloning, Molecular, Eating, Exocytosis, Genotype, Glucose Clamp Technique, Insulin, Insulin Secretion, Islets of Langerhans, Mice, Mice, Knockout, Molecular Sequence Data, Perfusion, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Recombinant Proteins, Sulfonylurea Receptors
Added December 10, 2013
2 Communities
5 Members
1 Resources
21 MeSH Terms
Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function.
Sorensen SD, Macek TA, Cai Z, Saugstad JA, Conn PJ
(2002) Mol Pharmacol 61: 1303-12
MeSH Terms: Amino Acid Substitution, Animals, Calmodulin, Cells, Cultured, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP-Dependent Protein Kinases, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Humans, Phosphorylation, Point Mutation, Potassium Channel Blockers, Potassium Channels, Potassium Channels, Inwardly Rectifying, Protein Kinase C, Rats, Receptors, Metabotropic Glutamate, Second Messenger Systems, Serine, Transfection
Added February 19, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function.
Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO
(2001) Biochem Biophys Res Commun 284: 918-22
MeSH Terms: Animals, Calcium, Cells, Cultured, Exocytosis, Female, Imidazoles, In Vitro Techniques, Indoles, Insulin, Insulin Secretion, Islets of Langerhans, Kinetics, Membrane Potentials, Mice, Mice, Knockout, Oocytes, Potassium Channel Blockers, Potassium Channels, Potassium Channels, Inwardly Rectifying, Promoter Regions, Genetic, Reference Values, Xenopus laevis
Added May 27, 2010
0 Communities
1 Members
1 Resources
22 MeSH Terms