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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 31 to 40 of 43

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Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy.
Donahue JP, Dowdy D, Ratnam KK, Hulgan T, Price J, Unutmaz D, Nicotera J, Raffanti S, Becker M, Haas DW
(2003) Clin Pharmacol Ther 73: 78-86
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Adult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Female, HIV Protease Inhibitors, HIV Seropositivity, Humans, Male, Nelfinavir, T-Lymphocytes
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA
(2002) Mol Pharmacol 61: 974-81
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Caco-2 Cells, Humans, Models, Molecular, Protein Conformation, Structure-Activity Relationship, Verapamil, Vinblastine
Added March 27, 2014
1 Communities
1 Members
2 Resources
8 MeSH Terms
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA
(2002) Mol Pharmacol 61: 964-73
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Antineoplastic Agents, Phytogenic, Caco-2 Cells, Ergonovine, Fluoxetine, Humans, Models, Molecular, Oxytocics, Protein Conformation, Serotonin Uptake Inhibitors, Structure-Activity Relationship, Swine, Transfection, Vinblastine
Added March 27, 2014
1 Communities
1 Members
2 Resources
15 MeSH Terms
Identification of functionally variant MDR1 alleles among European Americans and African Americans.
Kim RB, Leake BF, Choo EF, Dresser GK, Kubba SV, Schwarz UI, Taylor A, Xie HG, McKinsey J, Zhou S, Lan LB, Schuetz JD, Schuetz EG, Wilkinson GR
(2001) Clin Pharmacol Ther 70: 189-99
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Africa, Alleles, Anti-Allergic Agents, Area Under Curve, Blacks, Cloning, Molecular, DNA Primers, Digoxin, Enzyme Inhibitors, Europe, Genes, MDR, Genetic Variation, Genotype, Haplotypes, Humans, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Terfenadine, Time Factors, Whites
Added March 27, 2014
1 Communities
1 Members
2 Resources
22 MeSH Terms
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.
Wandel C, Kim RB, Guengerich FP, Wood AJ
(2000) Drug Metab Dispos 28: 895-8
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Aryl Hydrocarbon Hydroxylases, Biological Transport, Caco-2 Cells, Calcium Channel Blockers, Cells, Cultured, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Dose-Response Relationship, Drug, Enzyme Inhibitors, Humans, Mibefradil, Microsomes, Liver, Oxidoreductases, N-Demethylating
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB
(2000) Drug Metab Dispos 28: 655-60
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Biological Transport, Brain, Caco-2 Cells, Dibenzocycloheptenes, HIV Protease Inhibitors, Humans, Inhibitory Concentration 50, Male, Mice, Quinolines, Testis
Added March 27, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB
(1999) Drug Metab Dispos 27: 866-71
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Anion Transport Proteins, Biological Transport, Active, Caco-2 Cells, Carrier Proteins, Genes, MDR, HeLa Cells, Histamine H1 Antagonists, Humans, LLC-PK1 Cells, Mice, Rats, Swine, Terfenadine, Tissue Distribution, Transfection, Vaccinia virus
Added March 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR
(1999) Pharm Res 16: 408-14
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Aryl Hydrocarbon Hydroxylases, Biological Transport, Caco-2 Cells, Cells, Cultured, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Resistance, Multiple, Enzyme Inhibitors, Humans, Male, Mice, Oxidoreductases, N-Demethylating, Pharmacokinetics, Substrate Specificity
Added March 27, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments].
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM
(1999) Circulation 99: 552-7
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Biological Transport, Active, Caco-2 Cells, Cardiovascular Agents, Digoxin, Drug Interactions, Drug Resistance, Multiple, Humans, Mice, Quinidine, Tissue Distribution
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms
The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein.
Lutterbach B, Sun D, Schuetz J, Hiebert SW
(1998) Mol Cell Biol 18: 3604-11
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Dimerization, Gene Expression Regulation, Neoplastic, Humans, Leukemia, Myeloid, Neoplasm Proteins, Oncogene Proteins, Fusion, Point Mutation, Promoter Regions, Genetic, Proto-Oncogene Protein c-ets-1, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, RUNX1 Translocation Partner 1 Protein, Recombinant Fusion Proteins, Repressor Proteins, Structure-Activity Relationship, Transcription Factors, Translocation, Genetic, Tumor Cells, Cultured, Zinc Fingers
Added June 10, 2010
1 Communities
1 Members
0 Resources
24 MeSH Terms