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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 28 of 28

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Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.
Lewis DF, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP
(1999) Toxicology 139: 53-79
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Bacterial Proteins, Cricetinae, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Flatfishes, Humans, Hydrogen Bonding, Mice, Mixed Function Oxygenases, Models, Molecular, Mutagenesis, Site-Directed, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Rabbits, Rats, Sequence Homology, Amino Acid, Species Specificity, Structure-Activity Relationship, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype.
Guengerich FP, Parikh A, Turesky RJ, Josephy PD
(1999) Mutat Res 428: 115-24
MeSH Terms: Amino Acid Substitution, Animals, Carcinogens, Environmental, Cytochrome P-450 CYP1A2, Humans, Liver, Mutagenicity Tests, Mutagens, Pyrenes, Rats, Species Specificity, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Symposium overview: Characterization of xenobiotic metabolizing enzyme function using heterologous expression systems.
Townsend AJ, Kiningham KK, St Clair D, Tephly TR, Morrow CS, Guengerich FP
(1999) Toxicol Sci 48: 143-50
MeSH Terms: Animals, Enzymes, Gene Transfer Techniques, Humans, Organisms, Genetically Modified, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds.
Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H
(1997) Cancer Res 57: 4757-64
MeSH Terms: Animals, Anthracenes, Anticarcinogenic Agents, Benzyl Compounds, Carcinogens, Cyanates, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System, Humans, Male, Microsomes, Microsomes, Liver, Organoselenium Compounds, Oxazines, Oxidation-Reduction, Rats, Rats, Sprague-Dawley, Saccharomyces cerevisiae, Salmonella typhimurium, Sodium Selenite, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.
Shimada T, Gillam EM, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H
(1997) Drug Metab Dispos 25: 617-22
MeSH Terms: Antibodies, Aryl Hydrocarbon Hydroxylases, Catalysis, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, Kinetics, Microsomes, Liver, Recombinant Proteins, Saccharomyces cerevisiae, Substrate Specificity, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
New applications of bacterial systems to problems in toxicology.
Guengerich FP, Gillam EM, Shimada T
(1996) Crit Rev Toxicol 26: 551-83
MeSH Terms: Amino Acid Sequence, Animals, Bacteria, Biotransformation, Cytochrome P-450 Enzyme System, DNA, Complementary, Gene Expression Regulation, Enzymologic, Humans, Immunoblotting, Molecular Sequence Data, Mutagenicity Tests, Recombinant Proteins, SOS Response, Genetics, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Expression of P-450 enzyme activities in heterologous cells by transfection.
Waterman MR, Mason JI, Zuber MX, Lorence MC, Clark BJ, Trant JM, Barnes HJ, Simpson ER, Estabrook RW
(1989) Arch Toxicol Suppl 13: 155-63
MeSH Terms: Amino Acid Sequence, Animals, Cattle, Cloning, Molecular, Cytochrome P-450 Enzyme System, Endoplasmic Reticulum, Gene Expression Regulation, Humans, Mitochondria, Molecular Sequence Data, Structure-Activity Relationship, Transfection, Xenobiotics
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue.
Guengerich FP
(1990) Pharmacol Ther 45: 299-307
MeSH Terms: Animals, Humans, Lung, Mixed Function Oxygenases, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms