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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 40

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The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.
Kim W, Seok Kang Y, Soo Kim J, Shin NY, Hanks SK, Song WK
(2008) Mol Biol Cell 19: 2135-46
MeSH Terms: Animals, Cell Cycle, Cell Nucleus, Cell Proliferation, Cells, Cultured, Crk-Associated Substrate Protein, Extracellular Matrix, Humans, Integrins, Mice, Phosphorylation, Phosphotyrosine, Protein Binding, Protein Transport, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad3 Protein, Transcription, Genetic, Transforming Growth Factor beta
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.
Deane NG, Manning HC, Foutch AC, Washington MK, Aronow BJ, Aronow BA, Bornhop DJ, Coffey RJ
(2007) Mol Cancer Res 5: 341-9
MeSH Terms: Animals, Biomarkers, Tumor, Carbocyanines, Colonic Neoplasms, Diagnosis, Differential, Fluorescent Dyes, Inflammation, Isoquinolines, Mice, Mice, Knockout, Molecular Structure, Receptors, GABA-A, Smad3 Protein, Spectroscopy, Near-Infrared, Staining and Labeling
Added May 10, 2013
1 Communities
4 Members
0 Resources
15 MeSH Terms
A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling.
Brown KA, Pietenpol JA, Moses HL
(2007) J Cell Biochem 101: 9-33
MeSH Terms: Animals, Fibroblasts, Gene Expression Regulation, Mice, Mice, Knockout, Models, Biological, Signal Transduction, Smad2 Protein, Smad3 Protein, Transcription Factors, Transcription, Genetic, Transforming Growth Factor beta
Added February 17, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Convergence of p53 and transforming growth factor beta (TGFbeta) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells.
Wang SE, Narasanna A, Whitell CW, Wu FY, Friedman DB, Arteaga CL
(2007) J Biol Chem 282: 5661-9
MeSH Terms: Cell Line, Tumor, Cell Movement, Epithelial Cells, Genes, Tumor Suppressor, Humans, Mammary Glands, Human, Promoter Regions, Genetic, Serpins, Signal Transduction, Smad2 Protein, Smad3 Protein, Transcriptional Activation, Transforming Growth Factor beta, Tumor Suppressor Protein p53, Up-Regulation
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Renal bone morphogenetic protein-7 protects against diabetic nephropathy.
Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R
(2006) J Am Soc Nephrol 17: 2504-12
MeSH Terms: Animals, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Fibrosis, Humans, Inhibitor of Differentiation Protein 1, Kidney, Male, Mice, Mice, Transgenic, Phosphoenolpyruvate Carboxykinase (GTP), Plasminogen Activator Inhibitor 1, Podocytes, Promoter Regions, Genetic, Smad1 Protein, Smad2 Protein, Smad3 Protein, Smad5 Protein, Transforming Growth Factor beta
Added January 5, 2011
2 Communities
1 Members
0 Resources
21 MeSH Terms
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.
Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D
(2005) Circ Res 97: 900-7
MeSH Terms: Actins, Cell Differentiation, Cells, Cultured, Connective Tissue Growth Factor, Fibroblasts, Fibrosis, Humans, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Myocardium, NADPH Oxidase 4, NADPH Oxidases, RNA, Messenger, Reactive Oxygen Species, Smad2 Protein, Smad3 Protein, Superoxides, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added February 17, 2016
0 Communities
1 Members
0 Resources
19 MeSH Terms
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML
(2005) Free Radic Biol Med 38: 375-87
MeSH Terms: Activating Transcription Factor 3, Animals, Catalase, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Glutamate-Cysteine Ligase, Glutathione, Glutathione Transferase, Humans, Inactivation, Metabolic, Mice, RNA, Messenger, Reactive Oxygen Species, Signal Transduction, Smad3 Protein, Trans-Activators, Transcription Factors, Transforming Growth Factor beta
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Structural basis of heteromeric smad protein assembly in TGF-beta signaling.
Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K
(2004) Mol Cell 15: 813-23
MeSH Terms: Animals, Biomarkers, Tumor, COS Cells, Crystallography, X-Ray, DNA-Binding Proteins, Hot Temperature, Macromolecular Substances, Models, Molecular, Molecular Conformation, Phosphorylation, Polymers, Protein Structure, Tertiary, Protein Subunits, Signal Transduction, Smad2 Protein, Smad3 Protein, Temperature, Trans-Activators, Transforming Growth Factor beta
Added January 5, 2011
2 Communities
1 Members
0 Resources
19 MeSH Terms
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, Moses HL
(2004) Breast Cancer Res 6: R215-31
MeSH Terms: Actins, Animals, Cadherins, Cell Adhesion, Cell Cycle, Cell Line, Transformed, Cell Line, Tumor, Cell Movement, Cells, Cultured, DNA-Binding Proteins, Disease Progression, Epithelial Cells, Humans, In Vitro Techniques, Membrane Proteins, Mesoderm, Mice, Neoplasm Invasiveness, Neoplasm Proteins, Phenotype, Phosphoproteins, Phosphorylation, Protein Processing, Post-Translational, Smad2 Protein, Smad3 Protein, Trans-Activators, Transforming Growth Factor beta, Transforming Growth Factor beta1, Zonula Occludens-1 Protein
Added February 17, 2014
0 Communities
2 Members
0 Resources
29 MeSH Terms
Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.
Mithani SK, Balch GC, Shiou SR, Whitehead RH, Datta PK, Beauchamp RD
(2004) J Surg Res 117: 296-305
MeSH Terms: Animals, Apoptosis, Cell Division, Cell Line, Colon, DNA-Binding Proteins, Growth Inhibitors, Intestinal Mucosa, Mice, Mice, Transgenic, Mutation, Promoter Regions, Genetic, Smad3 Protein, Trans-Activators, Transforming Growth Factor beta
Added June 14, 2013
1 Communities
1 Members
0 Resources
15 MeSH Terms