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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 148

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TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
Le Bras GF, Taylor C, Koumangoye RB, Revetta F, Loomans HA, Andl CD
(2015) Exp Cell Res 330: 29-42
MeSH Terms: ADAM Proteins, ADAMTS1 Protein, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Movement, Cell Proliferation, Esophageal Neoplasms, Fibroblasts, Heparin-binding EGF-like Growth Factor, Humans, Interleukin-1, Keratinocytes, Nerve Tissue Proteins, Receptors, Immunologic, Receptors, Transforming Growth Factor beta, Transforming Growth Factor alpha, Transforming Growth Factor beta
Added October 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.
Jovanović B, Beeler JS, Pickup MW, Chytil A, Gorska AE, Ashby WJ, Lehmann BD, Zijlstra A, Pietenpol JA, Moses HL
(2014) Breast Cancer Res 16: R69
MeSH Terms: Animals, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Cell Transformation, Neoplastic, Cluster Analysis, Disease Models, Animal, Female, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Heterografts, Humans, Integrin alpha2, Mesenchymal Stem Cells, Mice, Proteoglycans, RNA, Messenger, RNA, Small Interfering, Receptors, Transforming Growth Factor beta, Spheroids, Cellular, Triple Negative Breast Neoplasms, Tumor Burden, Tumor Cells, Cultured
Added July 10, 2014
1 Communities
4 Members
0 Resources
26 MeSH Terms
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A
(2014) J Clin Invest 124: 3295-310
MeSH Terms: Animals, Collagen, Epithelial-Mesenchymal Transition, Fibrosis, Integrin alpha1, Integrin alpha1beta1, Kidney, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad Proteins, Smad2 Protein, Smad3 Protein, Tyrosine, Ureteral Obstruction
Added October 27, 2014
2 Communities
4 Members
1 Resources
23 MeSH Terms
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J
(2013) Nature 499: 306-11
MeSH Terms: Animals, Cells, Cultured, Endothelium, Vascular, Glycoproteins, In Vitro Techniques, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Transforming Growth Factor beta, Retinal Neovascularization, Retinal Vessels, Signal Transduction, Transforming Growth Factor beta1
Added September 6, 2013
1 Communities
0 Members
0 Resources
13 MeSH Terms
Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.
Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL
(2013) Cancer Res 73: 5336-46
MeSH Terms: Animals, Carcinogenesis, Collagen, Enzyme Inhibitors, Female, Fibroblasts, Focal Adhesion Kinase 1, Humans, In Situ Hybridization, Keratin-14, Lung Neoplasms, Mammary Neoplasms, Experimental, Mice, Mice, Transgenic, Microscopy, Atomic Force, Myeloid Cells, Phosphorylation, Protein-Lysine 6-Oxidase, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Stromal Cells, Transforming Growth Factor beta
Added February 17, 2014
1 Communities
2 Members
0 Resources
24 MeSH Terms
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
Bhola NE, Balko JM, Dugger TC, Kuba MG, Sánchez V, Sanders M, Stanford J, Cook RS, Arteaga CL
(2013) J Clin Invest 123: 1348-58
MeSH Terms: Animals, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Gene Expression, Gene Knockdown Techniques, Humans, Interleukin-8, Mice, Mice, Nude, Neoplastic Stem Cells, Paclitaxel, Protein-Serine-Threonine Kinases, Pyrazoles, Quinolines, RNA, Small Interfering, Receptor, ErbB-2, Receptor, Transforming Growth Factor-beta Type I, Receptors, Estrogen, Receptors, Progesterone, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad4 Protein, Spheroids, Cellular, Transforming Growth Factor beta, Xenograft Model Antitumor Assays
Added September 3, 2013
1 Communities
5 Members
0 Resources
28 MeSH Terms
Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Moses HL, Koike K
(2013) Cancer Res 73: 2221-34
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Blotting, Western, Carcinoma, Pancreatic Ductal, Cell Proliferation, Deoxycytidine, Enzyme-Linked Immunosorbent Assay, Erlotinib Hydrochloride, Flow Cytometry, Immunoenzyme Techniques, Immunoprecipitation, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinases, Pancreatic Neoplasms, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins p21(ras), Quinazolines, RNA, Messenger, Real-Time Polymerase Chain Reaction, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Survival Rate, Tumor Cells, Cultured
Added March 7, 2014
1 Communities
1 Members
0 Resources
29 MeSH Terms
Deleting the TGF-β receptor attenuates acute proximal tubule injury.
Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R
(2012) J Am Soc Nephrol 23: 2001-11
MeSH Terms: Acute Kidney Injury, Animals, Apoptosis, Kidney Cortex, Kidney Tubules, Proximal, Male, Mercuric Chloride, Mice, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Smad Proteins, Transforming Growth Factor beta
Added February 24, 2014
1 Communities
4 Members
1 Resources
13 MeSH Terms
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.
Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup MW, Gorska AE, Zijlstra A, Moses HL
(2012) Breast Cancer Res 14: R98
MeSH Terms: Animals, Cadherins, Cell Communication, Cell Line, Tumor, Cell Movement, Epithelial-Mesenchymal Transition, Fibroblasts, Gene Expression Regulation, Neoplastic, Gene Knockout Techniques, Humans, Intercellular Junctions, Mice, Neoplasms, Phenotype, Protein Transport, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Stromal Cells, Transforming Growth Factor beta, beta Catenin
Added February 17, 2014
1 Communities
2 Members
0 Resources
22 MeSH Terms
Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties.
Novitskiy SV, Pickup MW, Chytil A, Polosukhina D, Owens P, Moses HL
(2012) J Leukoc Biol 92: 641-51
MeSH Terms: Animals, Antigen Presentation, Cell Separation, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Macrophages, Mice, Mice, Knockout, Myeloid Cells, Neoplasms, Experimental, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Transforming Growth Factor beta, Tumor Microenvironment
Added February 17, 2014
1 Communities
2 Members
0 Resources
17 MeSH Terms