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Results: 21 to 30 of 164

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N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.
Felts AS, Rodriguez AL, Morrison RD, Venable DF, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
(2016) Bioorg Med Chem Lett 26: 1894-900
MeSH Terms: Allosteric Regulation, Animals, Central Nervous System, Dose-Response Relationship, Drug, Male, Mice, Molecular Structure, Pyrazoles, Pyrimidines, Rats, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added April 6, 2017
0 Communities
3 Members
0 Resources
13 MeSH Terms
The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia.
Ponnazhagan R, Harms AS, Thome AD, Jurkuvenaite A, Gogliotti R, Niswender CM, Conn PJ, Standaert DG
(2016) J Neuroimmune Pharmacol 11: 231-7
MeSH Terms: Allosteric Regulation, Animals, Anti-Inflammatory Agents, Cells, Cultured, Dose-Response Relationship, Drug, Inflammation, Inflammation Mediators, Mice, Mice, Inbred C57BL, Mice, Knockout, Microglia, Pyrimidines, Receptors, Metabotropic Glutamate, Thiazoles
Added April 6, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors.
Tadokoro T, Gao X, Hong CC, Hotten D, Hogan BL
(2016) Development 143: 764-73
MeSH Terms: Animals, Apoptosis, Basement Membrane, Bone Morphogenetic Proteins, Cell Differentiation, Cell Proliferation, Epithelial Cells, Green Fluorescent Proteins, Ligands, Lung, Male, Mice, Mice, Inbred C57BL, Pyrazoles, Pyrimidines, Regeneration, Respiratory Mucosa, Signal Transduction, Stem Cells, Trachea
Added February 22, 2016
1 Communities
1 Members
0 Resources
20 MeSH Terms
The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.
Lima GM, Corazza BJ, Moraes RM, de Oliveira FE, de Oliveira LD, Franco GC, Perrien DS, Elefteriou F, Anbinder AL
(2016) J Periodontal Res 51: 661-8
MeSH Terms: Alveolar Bone Loss, Animals, Collagen, Disease Models, Animal, Gingiva, Ligation, Male, Mandible, Periodontal Attachment Loss, Periodontal Diseases, Periodontitis, Pyrimidines, Rats, Rats, Wistar, Serotonin, X-Ray Microtomography
Added April 13, 2017
0 Communities
2 Members
0 Resources
16 MeSH Terms
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
(2015) Bioorg Med Chem Lett 25: 5115-20
MeSH Terms: Allosteric Regulation, Animals, Brain, Dogs, Humans, Ligands, Male, Motor Activity, Pyrazoles, Pyrimidines, Pyrimidinones, Rats, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Structure-Activity Relationship
Added February 18, 2016
0 Communities
4 Members
0 Resources
15 MeSH Terms
Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis.
Johung KL, Yeh N, Desai NB, Williams TM, Lautenschlaeger T, Arvold ND, Ning MS, Attia A, Lovly CM, Goldberg S, Beal K, Yu JB, Kavanagh BD, Chiang VL, Camidge DR, Contessa JN
(2016) J Clin Oncol 34: 123-9
MeSH Terms: Adult, Aged, Anaplastic Lymphoma Kinase, Antineoplastic Agents, Brain Neoplasms, Carbazoles, Carcinoma, Non-Small-Cell Lung, Cranial Irradiation, Crizotinib, Disease-Free Survival, Female, Follow-Up Studies, Gene Rearrangement, Humans, Kaplan-Meier Estimate, Karnofsky Performance Status, Lung Neoplasms, Male, Middle Aged, Molecular Targeted Therapy, Neoplasm Staging, Piperidines, Prognosis, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Pyrazoles, Pyridines, Pyrimidines, Radiosurgery, Receptor Protein-Tyrosine Kinases, Risk Assessment, Risk Factors, Smoking, Sulfones
Added January 26, 2016
0 Communities
1 Members
0 Resources
34 MeSH Terms
Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.
Moslehi JJ, Deininger M
(2015) J Clin Oncol 33: 4210-8
MeSH Terms: Aniline Compounds, Antineoplastic Agents, Cardiovascular System, Clinical Trials as Topic, Dasatinib, Fusion Proteins, bcr-abl, Humans, Hypertension, Imatinib Mesylate, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Molecular Targeted Therapy, Nitriles, Protein Kinase Inhibitors, Pyridazines, Pyrimidines, Quinolines
Added March 6, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Characterization of nitrogen mustard formamidopyrimidine adduct formation of bis(2-chloroethyl)ethylamine with calf thymus DNA and a human mammary cancer cell line.
Gruppi F, Hejazi L, Christov PP, Krishnamachari S, Turesky RJ, Rizzo CJ
(2015) Chem Res Toxicol 28: 1850-60
MeSH Terms: Animals, Cattle, Cell Line, Tumor, DNA, Humans, Mechlorethamine, Nitrogen Mustard Compounds, Pyrimidines, Thymus Gland
Added January 7, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB
(2015) Gastroenterology 149: 1932-1943.e9
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Collagen, Deoxycytidine, Drug Resistance, Neoplasm, Gene Knockdown Techniques, Humans, Mice, Inbred C57BL, Mice, Nude, Mice, Transgenic, Molecular Targeted Therapy, Neoplasm Staging, Osteonectin, Pancreatic Neoplasms, Phosphorylation, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins p21(ras), Pyrazoles, Pyrimidines, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, STAT3 Transcription Factor, Signal Transduction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stromal Cells, Time Factors, Transcription Factors, Transfection, Tumor Burden, Tumor Microenvironment, Xenograft Model Antitumor Assays
Added October 15, 2015
2 Communities
3 Members
0 Resources
33 MeSH Terms
Shades of T790M: Intratumor Heterogeneity in EGFR-Mutant Lung Cancer.
Ichihara E, Lovly CM
(2015) Cancer Discov 5: 694-6
MeSH Terms: Acrylamides, Drug Resistance, Neoplasm, ErbB Receptors, Humans, Lung Neoplasms, Protein Kinase Inhibitors, Pyrimidines, Small Cell Lung Carcinoma
Added January 26, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms