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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 80

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BRAFV600E-mutant melanoma presenting with cardiac involvement.
Johnson DB, Sosman JA
(2014) J Natl Compr Canc Netw 12: 611-5
MeSH Terms: Adult, Heart Neoplasms, Humans, Male, Melanoma, Mutation, Proto-Oncogene Proteins B-raf, Skin Neoplasms
Added June 27, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Beyond histology: translating tumor genotypes into clinically effective targeted therapies.
Meador CB, Micheel CM, Levy MA, Lovly CM, Horn L, Warner JL, Johnson DB, Zhao Z, Anderson IA, Sosman JA, Vnencak-Jones CL, Dahlman KB, Pao W
(2014) Clin Cancer Res 20: 2264-75
MeSH Terms: Anaplastic Lymphoma Kinase, Animals, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cell Transformation, Neoplastic, Drug Resistance, Neoplasm, Genetic Testing, Genetic Variation, Genomics, Genotype, Humans, Lung Neoplasms, Melanoma, Molecular Targeted Therapy, Mutation, Neoplasms, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Receptor Protein-Tyrosine Kinases
Added March 10, 2014
0 Communities
6 Members
0 Resources
19 MeSH Terms
Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Imielinski M, Greulich H, Kaplan B, Araujo L, Amann J, Horn L, Schiller J, Villalona-Calero MA, Meyerson M, Carbone DP
(2014) J Clin Invest 124: 1582-6
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Aged, Amino Acid Substitution, Antineoplastic Agents, Cell Transformation, Neoplastic, DNA, Neoplasm, Female, Humans, Lung Neoplasms, Molecular Targeted Therapy, Mutation, Missense, Niacinamide, Oncogenes, Phenylurea Compounds, Proto-Oncogene Proteins A-raf, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf, Sorafenib
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.
McArthur GA, Chapman PB, Robert C, Larkin J, Haanen JB, Dummer R, Ribas A, Hogg D, Hamid O, Ascierto PA, Garbe C, Testori A, Maio M, Lorigan P, Lebbé C, Jouary T, Schadendorf D, O'Day SJ, Kirkwood JM, Eggermont AM, Dréno B, Sosman JA, Flaherty KT, Yin M, Caro I, Cheng S, Trunzer K, Hauschild A
(2014) Lancet Oncol 15: 323-32
MeSH Terms: Adult, Aged, Dacarbazine, Disease-Free Survival, Female, Follow-Up Studies, Humans, Indoles, Male, Melanoma, Middle Aged, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Sulfonamides, Vemurafenib
Added March 20, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas.
Wang R, Pan Y, Li C, Zhang H, Garfield D, Li Y, Ye T, Hu H, Luo X, Li H, Zhang Y, Zhang J, Zhou X, Shen L, Pao W, Sun Y, Chen H
(2014) J Thorac Oncol 9: 760-8
MeSH Terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Carcinoma, Adenosquamous, Class I Phosphatidylinositol 3-Kinases, Disease-Free Survival, ErbB Receptors, Female, Genotype, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion, Phosphatidylinositol 3-Kinases, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-ret, Proto-Oncogene Proteins p21(ras), Receptor Protein-Tyrosine Kinases, Receptor, ErbB-2, Survival Rate, ras Proteins
Added March 10, 2014
0 Communities
1 Members
0 Resources
28 MeSH Terms
BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition.
Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W
(2013) Clin Cancer Res 19: 6696-702
MeSH Terms: Adult, Cell Line, Tumor, Female, High-Throughput Nucleotide Sequencing, Humans, MAP Kinase Signaling System, Male, Melanoma, Mitogen-Activated Protein Kinase Kinases, Multienzyme Complexes, Mutation, Oncogene Proteins, Fusion, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Sulfate Adenylyltransferase
Added March 10, 2014
1 Communities
4 Members
0 Resources
16 MeSH Terms
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy.
Shi H, Hugo W, Kong X, Hong A, Koya RC, Moriceau G, Chodon T, Guo R, Johnson DB, Dahlman KB, Kelley MC, Kefford RF, Chmielowski B, Glaspy JA, Sosman JA, van Baren N, Long GV, Ribas A, Lo RS
(2014) Cancer Discov 4: 80-93
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Cell Line, Tumor, Clonal Evolution, Drug Resistance, Neoplasm, Female, Humans, Imidazoles, Indoles, Male, Melanoma, Middle Aged, Mitogen-Activated Protein Kinases, Oximes, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Skin Neoplasms, Sulfonamides, Vemurafenib, ras Proteins
Added March 20, 2014
0 Communities
3 Members
0 Resources
25 MeSH Terms
Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Mikhitarian K, Pollen M, Zhao Z, Shyr Y, Merchant NB, Parikh A, Revetta F, Washington MK, Vnencak-Jones C, Shi C
(2014) Mod Pathol 27: 665-74
MeSH Terms: Adenocarcinoma, Aged, Ampulla of Vater, Class I Phosphatidylinositol 3-Kinases, Common Bile Duct Neoplasms, DNA Mutational Analysis, Duodenal Neoplasms, ErbB Receptors, Female, Humans, Male, Middle Aged, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Signal Transduction, ras Proteins
Added March 7, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Beyond exon 2--the developing story of RAS mutations in colorectal cancer.
Berlin J
(2013) N Engl J Med 369: 1059-60
MeSH Terms: Antibodies, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Colorectal Neoplasms, ErbB Receptors, Fluorouracil, Genes, ras, Humans, Leucovorin, Organoplatinum Compounds, Panitumumab, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), ras Proteins
Added March 20, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Distinct molecular features of colorectal cancer in Ghana.
Raskin L, Dakubo JC, Palaski N, Greenson JK, Gruber SB
(2013) Cancer Epidemiol 37: 556-61
MeSH Terms: African Americans, Colorectal Neoplasms, DNA Mismatch Repair, DNA, Neoplasm, Exons, Female, Genes, ras, Ghana, Humans, Immunohistochemistry, Male, Microsatellite Instability, Middle Aged, Molecular Epidemiology, Paraffin Embedding, Proto-Oncogene Proteins B-raf
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms