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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 53

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Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
Sangai T, Akcakanat A, Chen H, Tarco E, Wu Y, Do KA, Miller TW, Arteaga CL, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F
(2012) Clin Cancer Res 18: 5816-28
MeSH Terms: Animals, Apoptosis, Biomarkers, Pharmacological, Breast Neoplasms, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Drug Synergism, Female, Heterocyclic Compounds, 3-Ring, Humans, In Vitro Techniques, Mice, Oncogene Protein v-akt, PTEN Phosphohydrolase, Paclitaxel, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Transplantation, Heterologous
Added September 3, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.
Blind RD, Suzawa M, Ingraham HA
(2012) Sci Signal 5: ra44
MeSH Terms: Binding Sites, Blotting, Western, Cell Nucleus, Chromatin Immunoprecipitation, HEK293 Cells, Humans, Kinetics, Models, Molecular, Molecular Structure, Mutation, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol Phosphates, Phosphorylation, Phosphotransferases (Alcohol Group Acceptor), Protein Binding, Protein Structure, Tertiary, RNA Interference, Signal Transduction, Steroidogenic Factor 1, Substrate Specificity
Added August 18, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Targeting nonclassical oncogenes for therapy in T-ALL.
Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG
(2012) Cancer Cell 21: 459-72
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Binding Sites, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Class I Phosphatidylinositol 3-Kinases, Class Ib Phosphatidylinositol 3-Kinase, Drug Design, Gene Silencing, Humans, Mice, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Protein Isoforms, Purines, Quinazolinones
Added March 5, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
(2012) Cell 149: 49-62
MeSH Terms: Animals, Body Size, Cell Count, Cell Proliferation, Cell Respiration, Energy Metabolism, Mice, Mice, Transgenic, Mitochondria, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-myc, Signal Transduction
Added December 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi.
Serezani CH, Kane S, Medeiros AI, Cornett AM, Kim SH, Marques MM, Lee SP, Lewis C, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M
(2012) Sci Signal 5: ra12
MeSH Terms: Actins, Animals, Candida albicans, Candidiasis, Cells, Cultured, Cofilin 1, Cyclic AMP, Cyclic AMP-Dependent Protein Kinase Type I, Cyclic AMP-Dependent Protein Kinase Type II, Dinoprostone, Female, Immune Tolerance, Macrophages, Alveolar, PTEN Phosphohydrolase, Phagocytosis, Phosphorylation, Rats, Rats, Wistar, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype
Added May 4, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
Vo K, Amarasinghe B, Washington K, Gonzalez A, Berlin J, Dang TP
(2011) Mol Cancer 10: 138
MeSH Terms: Amyloid Precursor Protein Secretases, Animals, Antibiotics, Antineoplastic, Cell Line, Tumor, Female, Humans, Mice, Mice, Nude, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphorylation, Receptors, Notch, Signal Transduction, Sirolimus
Added April 12, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD
(2011) Mol Cell 42: 36-49
MeSH Terms: Aged, Animals, Cell Line, Transformed, Cell Proliferation, Cellular Senescence, Class I Phosphatidylinositol 3-Kinases, Disease Models, Animal, Enzyme Activation, Female, Gene Expression Regulation, Neoplastic, Genes, ras, Humans, Male, Mice, Mice, Knockout, Mice, Transgenic, Middle Aged, Mutation, Neoplasms, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction
Added March 17, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA
(2011) Diabetes 60: 827-37
MeSH Terms: Alleles, Analysis of Variance, Animals, Apoptosis, Blotting, Western, Carrier Proteins, Cell Proliferation, Cell Size, Fluorescent Antibody Technique, Genotype, Glucose, Glucose Intolerance, Hyperglycemia, Insulin-Secreting Cells, Mice, Mice, Knockout, PTEN Phosphohydrolase, Phosphorylation, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction
Added December 5, 2013
7 Communities
2 Members
0 Resources
22 MeSH Terms
A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons.
Perdigoto AL, Chaudhry N, Barnes GN, Filbin MT, Carter BD
(2011) Mol Cell Neurosci 46: 235-44
MeSH Terms: Animals, CHO Cells, Cells, Cultured, Cerebral Cortex, Coculture Techniques, Cricetinae, Cricetulus, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Myelin-Associated Glycoprotein, Neurites, Neurons, PTEN Phosphohydrolase, Proto-Oncogene Proteins c-akt, Receptor, Nerve Growth Factor, rho GTP-Binding Proteins, rho-Associated Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP
(2010) Sci Signal 3: ra29
MeSH Terms: Animals, Cell Cycle Proteins, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Introns, Male, Mice, Mice, Transgenic, MicroRNAs, Minichromosome Maintenance Complex Component 7, Multigene Family, Nuclear Proteins, PTEN Phosphohydrolase, Prostatic Neoplasms, Proto-Oncogenes
Added December 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms