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Results: 21 to 30 of 34

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Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.
Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G
(2010) Toxicol Sci 115: 596-606
MeSH Terms: Administration, Inhalation, Animals, Chemical and Drug Induced Liver Injury, Enzymes, Gene Expression Regulation, Enzymologic, Genetic Predisposition to Disease, Hydrocarbons, Brominated, Inhalation Exposure, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, NF-E2-Related Factor 2, Oxidative Stress, Solvents
Added February 12, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Sekhar KR, Rachakonda G, Freeman ML
(2010) Toxicol Appl Pharmacol 244: 21-6
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Animals, Cullin Proteins, Cysteine, Cytoskeletal Proteins, Gene Expression Regulation, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Oxidation-Reduction, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Protein Structure, Tertiary, Structure-Activity Relationship, Sulfhydryl Compounds, Transcriptional Activation, Ubiquitination
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME
(2010) Toxicol Appl Pharmacol 244: 77-83
MeSH Terms: Animals, Antioxidants, Diabetes Mellitus, Type 2, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin-Secreting Cells, Ion Channels, Mitochondrial Proteins, NF-E2-Related Factor 2, Oxidative Stress, Reactive Oxygen Species, Signal Transduction, Uncoupling Protein 2
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not.
Burk RF, Hill KE, Nakayama A, Mostert V, Levander XA, Motley AK, Johnson DA, Johnson JA, Freeman ML, Austin LM
(2008) Free Radic Biol Med 44: 1617-23
MeSH Terms: Animals, Antioxidants, Gene Deletion, Glutathione Transferase, Heme Oxygenase-1, Liver, Male, Membrane Proteins, Mice, Mice, Transgenic, NF-E2-Related Factor 2, Oxidative Stress, Quinone Reductases, Selenium, Vitamin E Deficiency
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.
Brown SL, Sekhar KR, Rachakonda G, Sasi S, Freeman ML
(2008) Cancer Res 68: 364-8
MeSH Terms: Activating Transcription Factor 3, Animals, Antioxidants, Cells, Cultured, Gene Expression Regulation, Mice, NF-E2-Related Factor 2, Protein Binding, RNA, Small Interfering, Repressor Proteins, Response Elements, Signal Transduction, Stress, Physiological, Transfection
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid.
Pi J, Zhang Q, Woods CG, Wong V, Collins S, Andersen ME
(2008) Toxicol Appl Pharmacol 226: 236-43
MeSH Terms: Animals, Cell Line, Cell Nucleus, Cell Survival, Dose-Response Relationship, Drug, Drug Antagonism, Free Radical Scavengers, Gene Expression, Hypochlorous Acid, Macrophages, Mice, NF-E2-Related Factor 2, Oxidants, Oxidative Stress
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.
Pi J, Bai Y, Reece JM, Williams J, Liu D, Freeman ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP
(2007) Free Radic Biol Med 42: 1797-806
MeSH Terms: Blotting, Western, Calcium, Calmodulin, Casein Kinase II, Cells, Cultured, Electrophoretic Mobility Shift Assay, Gene Expression Regulation, Humans, Immunoprecipitation, Keratinocytes, NF-E2-Related Factor 2, Phosphorylation, Plasmids, Protein Binding, Response Elements, Signal Transduction, Transcription, Genetic, Transcriptional Activation
Added March 5, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, Morrow JD, Freeman ML
(2007) J Biol Chem 282: 2529-37
MeSH Terms: Animals, Cell Cycle Proteins, Cell Line, Cullin Proteins, Fatty Acids, Omega-3, Gene Expression Regulation, Genes, Reporter, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Mice, Molecular Structure, NF-E2-Related Factor 2, Oxidation-Reduction, Oxidative Stress, Transcriptional Activation
Added March 5, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas.
Stacy DR, Ely K, Massion PP, Yarbrough WG, Hallahan DE, Sekhar KR, Freeman ML
(2006) Head Neck 28: 813-8
MeSH Terms: Adult, Aged, Biomarkers, Tumor, Carcinoma, Squamous Cell, Female, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Male, Middle Aged, Mouth Mucosa, NF-E2-Related Factor 2
Added March 5, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.
Hong F, Freeman ML, Liebler DC
(2005) Chem Res Toxicol 18: 1917-26
MeSH Terms: Amino Acid Sequence, Antineoplastic Agents, Cells, Cultured, Cysteine, DNA Adducts, Gene Expression Regulation, Neoplastic, Humans, Intracellular Signaling Peptides and Proteins, Isothiocyanates, Kelch-Like ECH-Associated Protein 1, Mass Spectrometry, Molecular Sequence Data, NF-E2-Related Factor 2, Proteins, Thiocyanates
Added March 20, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms