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MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.
Domina AM, Vrana JA, Gregory MA, Hann SR, Craig RW
(2004) Oncogene 23: 5301-15
MeSH Terms: Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Apoptosis, Binding Sites, CHO Cells, Carcinogens, Cell Line, Tumor, Cell Survival, Cricetinae, Dogs, Dose-Response Relationship, Drug, Enzyme Activation, Enzyme Inhibitors, Humans, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins, Okadaic Acid, Paclitaxel, Peptide Mapping, Phosphorylation, Precipitin Tests, Protein Kinase C, Protein Structure, Tertiary, Proto-Oncogene Proteins c-bcl-2, Signal Transduction, Tetradecanoylphorbol Acetate, Threonine, Time Factors, Transfection
Added March 20, 2014
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34 MeSH Terms