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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 48

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Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP
(2004) Chem Res Toxicol 17: 972-82
MeSH Terms: Biotransformation, Dose-Response Relationship, Drug, Escherichia coli, Humans, Hydrocarbons, Halogenated, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Salmonella typhimurium, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
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11 MeSH Terms
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
Liu L, Williams KM, Guengerich FP, Pegg AE
(2004) Chem Res Toxicol 17: 742-52
MeSH Terms: DNA Damage, DNA-Directed RNA Polymerases, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Hydrocarbons, Brominated, Mass Spectrometry, Mutagenicity Tests, O(6)-Methylguanine-DNA Methyltransferase, Plasmids, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Added May 26, 2014
0 Communities
1 Members
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10 MeSH Terms
Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.
Kim D, Kadlubar FF, Teitel CH, Guengerich FP
(2004) Chem Res Toxicol 17: 529-36
MeSH Terms: Carcinogens, Catalysis, Chromatography, High Pressure Liquid, Escherichia coli, Kinetics, Mass Spectrometry, Models, Theoretical, Mutagenicity Tests, NADP, NADPH-Ferrihemoprotein Reductase, Nitroso Compounds, Oxidation-Reduction, Quinolines, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
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14 MeSH Terms
N-hydroxyarylamines.
Guengerich FP
(2002) Drug Metab Rev 34: 607-23
MeSH Terms: Amines, Base Sequence, Cytochrome P-450 Enzyme System, DNA, Enzyme Activation, Escherichia coli, Guanine, Humans, Molecular Sequence Data, Molecular Structure, Mutagenicity Tests, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction
Added March 5, 2014
0 Communities
1 Members
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13 MeSH Terms
Mutagenicity of the malondialdehyde oligomerization products 2-(3'-oxo-1'-propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella.
Riggins JN, Marnett LJ
(2001) Mutat Res 497: 153-7
MeSH Terms: Dose-Response Relationship, Drug, Glutaral, Malondialdehyde, Mutagenicity Tests, Mutagens, Salmonella typhimurium, Thermodynamics
Added March 5, 2014
0 Communities
1 Members
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7 MeSH Terms
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalomethanes.
Wheeler JB, Stourman NV, Thier R, Dommermuth A, Vuilleumier S, Rose JA, Armstrong RN, Guengerich FP
(2001) Chem Res Toxicol 14: 1118-27
MeSH Terms: Animals, Bacteria, Catalysis, Dose-Response Relationship, Drug, Glutathione Transferase, Hydrocarbons, Halogenated, Hydrolases, Hydrolysis, Kinetics, Mammals, Methane, Mutagenicity Tests, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
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13 MeSH Terms
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes.
Wheeler JB, Stourman NV, Armstrong RN, Guengerich FP
(2001) Chem Res Toxicol 14: 1107-17
MeSH Terms: Alkanes, Animals, Bacteria, Catalysis, Ethane, Glutathione Transferase, Hydrocarbons, Halogenated, Hydrolysis, Kinetics, Mammals, Mustard Compounds, Mutagenicity Tests, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
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13 MeSH Terms
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase.
Oda Y, Aryal P, Terashita T, Gillam EM, Guengerich FP, Shimada T
(2001) Mutat Res 492: 81-90
MeSH Terms: Acetyltransferases, Amines, Arylamine N-Acetyltransferase, Carcinogens, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Enzyme Activation, Fluorenes, Heterocyclic Compounds, Humans, Isoenzymes, Mutagenicity Tests, Mutagens, NADPH-Ferrihemoprotein Reductase, Salmonella typhimurium, Sensitivity and Specificity
Added May 26, 2014
0 Communities
1 Members
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16 MeSH Terms
The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH
(2001) Carcinogenesis 22: 943-50
MeSH Terms: 2-Acetylaminofluorene, Animals, Bacterial Proteins, Biotransformation, Catalysis, Cell Line, Cytochrome P-450 CYP1A2, DNA-Directed DNA Polymerase, Escherichia coli Proteins, Gene Expression Regulation, Enzymologic, Glucuronides, Glucuronosyltransferase, Humans, Hydroxyacetylaminofluorene, Hydroxylation, Imidazoles, Isoenzymes, Mice, Mutagenicity Tests, Mutagens, Pyridines, Recombinant Proteins
Added May 26, 2014
0 Communities
1 Members
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22 MeSH Terms
Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine.
Plastaras JP, Riggins JN, Otteneder M, Marnett LJ
(2000) Chem Res Toxicol 13: 1235-42
MeSH Terms: Animals, Cattle, DNA, Lysine, Malondialdehyde, Mice, Mutagenicity Tests, Mutagens, Purines, Pyrimidines, Salmonella typhimurium, Thymine
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms