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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 232

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A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.
Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC
(2014) Clin Cancer Res 20: 2126-35
MeSH Terms: Amino Acid Chloromethyl Ketones, Animals, Apoptosis, Caspase 3, Caspase Inhibitors, Cell Line, Tumor, Colonic Neoplasms, Colorectal Neoplasms, Female, Fluorine Radioisotopes, Fluorobenzenes, Humans, Imidazoles, Immunoblotting, Immunohistochemistry, Indoles, Mice, Inbred C57BL, Mice, Nude, Organophosphates, Peptides, Positron-Emission Tomography, Protein Kinase Inhibitors, Quinazolines, Quinolines, Radiopharmaceuticals, Sulfonamides, Tissue Distribution, Xenograft Model Antitumor Assays
Added March 20, 2014
1 Communities
3 Members
0 Resources
28 MeSH Terms
Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.
Schultz MA, Hagan SS, Datta A, Zhang Y, Freeman ML, Sikka SC, Abdel-Mageed AB, Mondal D
(2014) PLoS One 9: e87204
MeSH Terms: Analysis of Variance, Cell Line, Tumor, Chromatin Immunoprecipitation, DNA Primers, Dihydrotestosterone, Electrophoretic Mobility Shift Assay, Humans, Immunoblotting, Luciferases, Male, NF-E2-Related Factor 2, Nuclear Respiratory Factor 1, Prostatic Neoplasms, Castration-Resistant, Real-Time Polymerase Chain Reaction, Receptors, Androgen, Transcriptional Activation
Added March 13, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA
(2014) FASEB J 28: 1735-44
MeSH Terms: 8-Hydroxy-2-(di-n-propylamino)tetralin, Adenylyl Cyclases, Animals, Animals, Newborn, Anxiety, Cells, Cultured, Cerebral Cortex, Depression, Female, Fluvoxamine, Hippocampus, Immunoblotting, Immunohistochemistry, Male, Mice, Phosphorylation, Piperazines, Proto-Oncogene Proteins c-akt, Pyridines, RGS Proteins, Receptor, Serotonin, 5-HT1A, Serotonin, Serotonin Antagonists, Serotonin Receptor Agonists, Serotonin Uptake Inhibitors, Signal Transduction
Added August 7, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.
Guckes KR, Kostakioti M, Breland EJ, Gu AP, Shaffer CL, Martinez CR, Hultgren SJ, Hadjifrangiskou M
(2013) Proc Natl Acad Sci U S A 110: 16592-7
MeSH Terms: Bacterial Proteins, DNA Primers, DNA Transposable Elements, Electrophoretic Mobility Shift Assay, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Immunoblotting, Mutagenesis, Quorum Sensing, Real-Time Polymerase Chain Reaction, Receptor Cross-Talk, Signal Transduction
Added August 6, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Wnt signaling potentiates nevogenesis.
Pawlikowski JS, McBryan T, van Tuyn J, Drotar ME, Hewitt RN, Maier AB, King A, Blyth K, Wu H, Adams PD
(2013) Proc Natl Acad Sci U S A 110: 16009-14
MeSH Terms: Animals, Cell Line, Tumor, Cellular Senescence, DNA Primers, HEK293 Cells, Humans, Immunoblotting, Immunohistochemistry, Melanocytes, Melanoma, Mice, Microarray Analysis, Nevus, Real-Time Polymerase Chain Reaction, Sequence Analysis, RNA, Wnt Signaling Pathway
Added March 17, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W
(2013) Proc Natl Acad Sci U S A 110: E3595-604
MeSH Terms: Animals, Crystallization, Dimerization, ErbB Receptors, HEK293 Cells, Humans, Immunoblotting, Immunoprecipitation, Lung Neoplasms, Mice, Models, Molecular, Mutation, Missense, NIH 3T3 Cells, Protein Conformation, Receptor, ErbB-2
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Garner AP, Bialucha CU, Sprague ER, Garrett JT, Sheng Q, Li S, Sineshchekova O, Saxena P, Sutton CR, Chen D, Chen Y, Wang H, Liang J, Das R, Mosher R, Gu J, Huang A, Haubst N, Zehetmeier C, Haberl M, Elis W, Kunz C, Heidt AB, Herlihy K, Murtie J, Schuller A, Arteaga CL, Sellers WR, Ettenberg SA
(2013) Cancer Res 73: 6024-35
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Breast Neoplasms, Cell Proliferation, ErbB Receptors, Female, Humans, Immunoblotting, Immunoprecipitation, Mice, Mice, Inbred BALB C, Mice, Inbred NOD, Mice, Nude, Mice, SCID, Neuregulin-1, Phosphorylation, Protein Conformation, Protein Multimerization, Proto-Oncogene Proteins c-akt, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Rate, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
2 Members
0 Resources
25 MeSH Terms
Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers.
Garrett JT, Sutton CR, Kurupi R, Bialucha CU, Ettenberg SA, Collins SD, Sheng Q, Wallweber J, Defazio-Eli L, Arteaga CL
(2013) Cancer Res 73: 6013-23
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Breast Neoplasms, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Immunoblotting, Immunoprecipitation, Lapatinib, Mice, Phosphorylation, Protein Multimerization, Proto-Oncogene Proteins c-akt, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Rate, Trastuzumab, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
2 Members
0 Resources
23 MeSH Terms
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.
Zhang R, Jha BK, Ogden KM, Dong B, Zhao L, Elliott R, Patton JT, Silverman RH, Weiss SR
(2013) Proc Natl Acad Sci U S A 110: 13114-9
MeSH Terms: 2',5'-Oligoadenylate Synthetase, Adenine Nucleotides, Amino Acid Sequence, Animals, Binding Sites, Capsid Proteins, Cell Line, Cells, Cultured, Endoribonucleases, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunoblotting, Macrophages, Mice, Mice, Knockout, Molecular Sequence Data, Murine hepatitis virus, Mutation, Oligoribonucleotides, Phosphoric Diester Hydrolases, RNA Virus Infections, RNA Viruses, Rotavirus, Sequence Homology, Amino Acid, Viral Nonstructural Proteins
Added April 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Relaxin treatment reverses insulin resistance in mice fed a high-fat diet.
Bonner JS, Lantier L, Hocking KM, Kang L, Owolabi M, James FD, Bracy DP, Brophy CM, Wasserman DH
(2013) Diabetes 62: 3251-60
MeSH Terms: Animals, Blood Glucose, Diet, High-Fat, Glucose, Immunoblotting, Immunohistochemistry, Insulin Resistance, Male, Mice, Mice, Inbred C57BL, Muscle, Skeletal, Relaxin
Added April 17, 2014
2 Communities
3 Members
0 Resources
12 MeSH Terms