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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 85

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Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.
Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A
(2012) J Biol Chem 287: 35139-35152
MeSH Terms: Amino Acid Substitution, Animals, Cell Line, Transformed, Collagen Type IV, Down-Regulation, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Humans, Integrin alpha1beta1, Laminin, Ligands, MAP Kinase Signaling System, Mice, Mice, Mutant Strains, Models, Molecular, Mutation, Missense, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Biosynthesis, Protein Structure, Tertiary
Added February 24, 2014
1 Communities
6 Members
1 Resources
20 MeSH Terms
CD98 increases renal epithelial cell proliferation by activating MAPKs.
Bulus N, Feral C, Pozzi A, Zent R
(2012) PLoS One 7: e40026
MeSH Terms: Amino Acids, Animals, Biological Transport, Cell Proliferation, Cell Survival, Enzyme Activation, Epithelial Cells, Extracellular Signal-Regulated MAP Kinases, Fusion Regulatory Protein 1, Heavy Chain, Humans, Kidney Tubules, Collecting, Large Neutral Amino Acid-Transporter 1, MAP Kinase Signaling System, Mice, Models, Biological, Serum, TOR Serine-Threonine Kinases, p38 Mitogen-Activated Protein Kinases
Added February 24, 2014
1 Communities
2 Members
1 Resources
18 MeSH Terms
PI3K/AKT and ERK regulate retinoic acid-induced neuroblastoma cellular differentiation.
Qiao J, Paul P, Lee S, Qiao L, Josifi E, Tiao JR, Chung DH
(2012) Biochem Biophys Res Commun 424: 421-6
MeSH Terms: Cell Differentiation, Extracellular Signal-Regulated MAP Kinases, G1 Phase Cell Cycle Checkpoints, Humans, Neuroblastoma, Phosphatidylinositol 3-Kinases, Phosphorylation, Proto-Oncogene Proteins c-akt, Resting Phase, Cell Cycle, Tretinoin
Added March 7, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ
(2012) J Neurosci 32: 8532-44
MeSH Terms: Animals, Arrestins, Behavior, Animal, Benzamides, Biphenyl Compounds, Brain, CHO Cells, Calcium, Cell Line, Corpus Striatum, Cricetinae, Cricetulus, Extracellular Signal-Regulated MAP Kinases, Extracellular Space, Fear, Gene Expression Profiling, Hippocampus, Humans, Male, Maze Learning, Membrane Potentials, Mice, Mice, Inbred C57BL, Muscarinic Agonists, Phosphorylation, Prefrontal Cortex, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1
Added March 7, 2014
1 Communities
5 Members
0 Resources
29 MeSH Terms
Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia.
Mancuso P, Myers MG, Goel D, Serezani CH, O'Brien E, Goldberg J, Aronoff DM, Peters-Golden M
(2012) J Immunol 189: 867-75
MeSH Terms: Amino Acid Substitution, Animals, Cells, Cultured, Extracellular Signal-Regulated MAP Kinases, Female, Immunity, Innate, Klebsiella Infections, Klebsiella pneumoniae, Leucine, MAP Kinase Signaling System, Macrophages, Alveolar, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pneumonia, Bacterial, Receptors, Leptin, Tyrosine
Added May 4, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, González-Angulo AM, Mills GB, Pinto JA, Gómez HL, Arteaga CL
(2012) Nat Med 18: 1052-9
MeSH Terms: Animals, Apoptosis, Breast Neoplasms, Cell Survival, Drug Resistance, Neoplasm, Dual-Specificity Phosphatases, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Genes, Neoplasm, Humans, Ki-67 Antigen, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinase Phosphatases, Neoadjuvant Therapy, Neoplasm, Residual, Paraffin Embedding, RNA, Messenger, Tissue Banks, Tissue Fixation, Treatment Outcome, ras Proteins
Added September 3, 2013
1 Communities
6 Members
0 Resources
27 MeSH Terms
Transactivation of EGFR by LPS induces COX-2 expression in enterocytes.
McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk DB, Weitkamp JH
(2012) PLoS One 7: e38373
MeSH Terms: Cell Line, Cyclooxygenase 2, Enterocytes, Epidermal Growth Factor, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Humans, Lipopolysaccharides, Matrix Metalloproteinases, Protein Binding, Signal Transduction, p38 Mitogen-Activated Protein Kinases
Added February 27, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH
(2012) Proc Natl Acad Sci U S A 109: 8710-5
MeSH Terms: Animals, Apoptosis, Astrocytoma, Blotting, Western, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Child, Cyclin-Dependent Kinase Inhibitor p16, Extracellular Signal-Regulated MAP Kinases, Female, Humans, Immunohistochemistry, Indoles, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Nude, Mice, SCID, Neural Stem Cells, Phosphorylation, Piperazines, Proto-Oncogene Proteins B-raf, Pyridines, Sulfonamides, Xenograft Model Antitumor Assays
Added August 21, 2012
1 Communities
1 Members
0 Resources
27 MeSH Terms
Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury.
Chen J, Chen JK, Harris RC
(2012) Kidney Int 82: 45-52
MeSH Terms: Acute Kidney Injury, Animals, Biomarkers, Blood Urea Nitrogen, Creatinine, Disease Models, Animal, Enzyme Activation, ErbB Receptors, Erlotinib Hydrochloride, Extracellular Signal-Regulated MAP Kinases, Gene Deletion, Kidney Tubules, Proximal, Mice, Mice, Inbred BALB C, Mice, Knockout, Phosphatidylinositol 3-Kinase, Phosphorylation, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Quinazolines, Recovery of Function, Reperfusion Injury, Time Factors
Added August 19, 2013
1 Communities
1 Members
0 Resources
23 MeSH Terms
Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.
Shi H, Moriceau G, Kong X, Lee MK, Lee H, Koya RC, Ng C, Chodon T, Scolyer RA, Dahlman KB, Sosman JA, Kefford RF, Long GV, Nelson SF, Ribas A, Lo RS
(2012) Nat Commun 3: 724
MeSH Terms: Adult, Aged, Antineoplastic Agents, Base Sequence, Benzimidazoles, Cell Line, Cell Line, Tumor, DNA Copy Number Variations, Drug Resistance, Neoplasm, Exome, Extracellular Signal-Regulated MAP Kinases, Female, Gene Amplification, HEK293 Cells, Humans, Indoles, MAP Kinase Kinase 1, Male, Melanoma, Middle Aged, Proto-Oncogene Proteins B-raf, Sequence Analysis, DNA, Sulfonamides, Vemurafenib
Added March 20, 2014
0 Communities
2 Members
0 Resources
24 MeSH Terms