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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 61

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Cytochromes P450 and drug discovery.
Lamb DC, Waterman MR, Kelly SL, Guengerich FP
(2007) Curr Opin Biotechnol 18: 504-12
MeSH Terms: Binding Sites, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Design, Enzyme Inhibitors, Models, Molecular, Molecular Structure, Protein Binding, Protein Structure, Tertiary
Added March 26, 2014
0 Communities
2 Members
0 Resources
9 MeSH Terms
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR
(2007) Antimicrob Agents Chemother 51: 3915-23
MeSH Terms: Amino Acid Sequence, Bacterial Proteins, Benzeneacetamides, Binding Sites, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Imidazoles, Models, Molecular, Molecular Structure, Mycobacterium tuberculosis, Sequence Homology, Amino Acid, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4.
Isin EM, Guengerich FP
(2007) J Biol Chem 282: 6863-74
MeSH Terms: Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Humans, Kinetics, Ligands, Models, Chemical, Pharmaceutical Preparations, Protein Binding, Recombinant Proteins, Spectrum Analysis, Thermodynamics, Titrimetry
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2).
Zhao B, Waterman MR, Isin EM, Sundaramoorthy M, Podust LM
(2006) Biochemistry 45: 7493-500
MeSH Terms: Binding Sites, Crystallization, Cytochrome P-450 Enzyme Inhibitors, Escherichia coli, Hydrogen Bonding, Imidazoles, Kinetics, Ligands, Malonates, Mixed Function Oxygenases, Models, Molecular, Naphthoquinones, Protein Conformation, Protein Structure, Secondary, Streptomyces coelicolor
Added February 12, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Inhaled nitric oxide attenuates hyperoxic lung injury in lambs.
Cotton RB, Sundell HW, Zeldin DC, Morrow JD, Roberts LJ, Hazinski TA, Law AB, Steele S
(2006) Pediatr Res 59: 142-6
MeSH Terms: Administration, Inhalation, Animals, Animals, Newborn, Bronchoalveolar Lavage Fluid, Cytochrome P-450 Enzyme Inhibitors, F2-Isoprostanes, Hyperoxia, Leukocytes, Nitric Oxide, Oxidative Stress, Pneumonia, Sheep, Domestic
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH
(2005) J Biol Chem 280: 27138-46
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Angiogenesis Inducing Agents, Animals, Cell Proliferation, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Eicosanoids, Endothelium, Vascular, Enzyme Inhibitors, Lipids, Mice, Neovascularization, Physiologic, Oxygenases, Phosphatidylinositol 3-Kinases, p38 Mitogen-Activated Protein Kinases
Added February 24, 2014
1 Communities
3 Members
0 Resources
16 MeSH Terms
Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin.
Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH
(2004) Toxicol Lett 153: 239-46
MeSH Terms: Catalysis, Cytochrome P-450 Enzyme Inhibitors, Enzyme Inhibitors, Hemin, Humans, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase
Added May 26, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
Remmel RP, Crews BC, Kozak KR, Kalgutkar AS, Marnett LJ, Algutkar AS
(2004) Drug Metab Dispos 32: 113-22
MeSH Terms: Animals, Bile, Biotransformation, Chromatography, High Pressure Liquid, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, In Vitro Techniques, Indomethacin, Injections, Intravenous, Isoenzymes, Mass Spectrometry, Membrane Proteins, Mice, Microsomes, Liver, Prostaglandin-Endoperoxide Synthases, Rats, Recombinant Proteins, Species Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide.
Kozak W, Aronoff DM, Boutaud O, Kozak A
(2003) Exp Biol Med (Maywood) 228: 786-94
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Arachidonic Acid, Carbon Radioisotopes, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dinoprostone, Dose-Response Relationship, Drug, Enzyme Induction, Enzyme Inhibitors, Lipopolysaccharides, Male, Monocytes, Proadifen, Prostaglandin-Endoperoxide Synthases, Rats, Rats, Sprague-Dawley, Time Factors
Added March 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Cytochrome P450 enzymes in the generation of commercial products.
Guengerich FP
(2002) Nat Rev Drug Discov 1: 359-66
MeSH Terms: Animals, Biodegradation, Environmental, Biosensing Techniques, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Industry, Humans, Prodrugs
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms