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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 33

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Estimation of the warfarin dose with clinical and pharmacogenetic data.
International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA
(2009) N Engl J Med 360: 753-64
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genotype, Humans, International Normalized Ratio, Least-Squares Analysis, Male, Middle Aged, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.
Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D
(2009) Blood 113: 3925-30
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genotype, Humans, International Normalized Ratio, Male, Middle Aged, Mixed Function Oxygenases, Substrate Specificity, Treatment Outcome, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
2 Members
0 Resources
14 MeSH Terms
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ
(2008) Blood 112: 1022-7
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Genomics, Genotype, Humans, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Retrospective Studies, Vitamin K Epoxide Reductases, Warfarin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Genetic determinants of dose and clinical outcomes in patients receiving oral anticoagulants.
Schwarz UI, Stein CM
(2006) Clin Pharmacol Ther 80: 7-12
MeSH Terms: Acenocoumarol, Administration, Oral, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Genotype, Humans, Mixed Function Oxygenases, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
CYP2C9 allelic variants: ethnic distribution and functional significance.
Xie HG, Prasad HC, Kim RB, Stein CM
(2002) Adv Drug Deliv Rev 54: 1257-70
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Asians, Blacks, Cytochrome P-450 CYP2C9, Gene Frequency, Humans, Polymorphism, Genetic, Promoter Regions, Genetic, Substrate Specificity, Whites
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K
(1999) Carcinogenesis 20: 1607-13
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Carcinogens, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Escherichia coli, Estradiol, Estrone, Humans, Hydroxylation, Progesterone, Steroid 16-alpha-Hydroxylase, Testosterone
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T
(1998) Biochem Pharmacol 56: 243-51
MeSH Terms: Amino Acid Substitution, Aryl Hydrocarbon Hydroxylases, Catalysis, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, DNA, Diclofenac, Flurbiprofen, Heterozygote, Humans, Hydroxylation, Oxidation-Reduction, Polymorphism, Genetic, RNA, Stereoisomerism, Steroid 16-alpha-Hydroxylase, Steroid Hydroxylases, Warfarin
Added May 26, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5.
Huang Z, Guengerich FP, Kaminsky LS
(1998) Carcinogenesis 19: 867-72
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Estrone, Humans, Microsomes, Liver, Mixed Function Oxygenases, Steroid 16-alpha-Hydroxylase, Steroid Hydroxylases, Substrate Specificity
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
Yamazaki H, Shaw PM, Guengerich FP, Shimada T
(1998) Chem Res Toxicol 11: 659-65
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Estradiol, Estrone, Humans, Hydroxylation, Microsomes, Liver, Mixed Function Oxygenases, Oxidation-Reduction, Steroid 16-alpha-Hydroxylase
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Yamazaki H, Gillam EM, Dong MS, Johnson WW, Guengerich FP, Shimada T
(1997) Arch Biochem Biophys 342: 329-37
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Chlorzoxazone, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Cytochromes b5, Escherichia coli, Ethanolamines, Humans, Hydroxylation, Mixed Function Oxygenases, Mutation, NADP, Nifedipine, Oxidation-Reduction, Phospholipids, Recombinant Proteins, Testosterone, Theophylline, Tolbutamide, Warfarin
Added May 26, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms