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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 21 to 30 of 42

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Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.
Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K
(2004) Chem Res Toxicol 17: 1077-85
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Breast, Breast Neoplasms, Cell Line, Tumor, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, DNA Adducts, Environmental Pollutants, Epithelial Cells, Female, Humans, Isomerism, Nitro Compounds, Oxidation-Reduction, Pyrenes, Rats, Recombinant Proteins, Tumor Cells, Cultured
Added May 26, 2014
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19 MeSH Terms
Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes.
Andrieux L, Langou√ęt S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A
(2004) Mol Pharmacol 65: 934-43
MeSH Terms: Animals, Butadienes, Cells, Cultured, Cytochrome P-450 CYP1A1, Dose-Response Relationship, Drug, Enzyme Induction, Enzyme Inhibitors, Hepatocytes, Humans, MAP Kinase Signaling System, Male, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Nitriles, Rats, Rats, Sprague-Dawley, Receptors, Aryl Hydrocarbon, Signal Transduction, Time Factors
Added May 26, 2014
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19 MeSH Terms
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.
Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH
(2004) J Biol Chem 279: 23969-76
MeSH Terms: Animals, Animals, Newborn, Blotting, Western, Brain, Cell Line, Cells, Cultured, Cytochrome P-450 CYP1A1, DNA, Gene Expression Regulation, Developmental, Hepatocytes, Humans, Kidney, Lactation, Ligands, Liver, Luciferases, Lung, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Models, Genetic, Polychlorinated Dibenzodioxins, Promoter Regions, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Tissue Distribution
Added May 26, 2014
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27 MeSH Terms
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Ueng YF, Jan WC, Lin LC, Chen TL, Guengerich FP, Chen CF
(2002) Drug Metab Dispos 30: 349-53
MeSH Terms: Alkaloids, Animals, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Humans, In Vitro Techniques, Indole Alkaloids, Kinetics, Magnetic Resonance Spectroscopy, Mice, Mice, Inbred C57BL, Microsomes, Liver, Oxidoreductases, Plant Extracts, Quinazolines, Structure-Activity Relationship, Substrate Specificity, Theophylline
Added May 26, 2014
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23 MeSH Terms
Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K
(2001) Drug Metab Dispos 29: 1176-82
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Biotransformation, Carcinogens, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Humans, Polycyclic Aromatic Hydrocarbons, Recombinant Proteins, Salmonella typhimurium
Added May 26, 2014
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11 MeSH Terms
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.
Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH
(2001) Am J Hum Genet 69: 138-47
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Breast Neoplasms, Case-Control Studies, Chromosome Mapping, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Estrogens, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Matched-Pair Analysis, Methyltransferases, Mutation, Missense, Polymorphism, Genetic, Reproducibility of Results, Sample Size, Statistics, Nonparametric, Whites
Added March 21, 2014
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23 MeSH Terms
Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points.
Anandatheerthavarada HK, Amuthan G, Biswas G, Robin MA, Murali R, Waterman MR, Avadhani NG
(2001) EMBO J 20: 2394-403
MeSH Terms: Adrenodoxin, Animals, Binding Sites, Cattle, Chromosome Mapping, Cross-Linking Reagents, Cytochrome P-450 CYP1A1, Evolution, Molecular, Flavodoxin, Mammals, Mitochondria, Liver, Models, Molecular, Mutagenesis, NADPH-Ferrihemoprotein Reductase, Protein Structure, Secondary, Rats, Two-Hybrid System Techniques
Added February 12, 2015
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17 MeSH Terms
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T
(2000) Mutat Res 472: 129-38
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, Mutagenicity Tests, Mutagens, NADPH-Ferrihemoprotein Reductase, Pyrenes, Recombinant Fusion Proteins, Salmonella typhimurium, Structure-Activity Relationship, Vehicle Emissions
Added May 26, 2014
0 Communities
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16 MeSH Terms
TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium.
Gannon M, Gilday D, Rifkind AB
(2000) Toxicol Appl Pharmacol 164: 24-37
MeSH Terms: Animals, Arachidonic Acid, Aryl Hydrocarbon Hydroxylases, Chick Embryo, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme System, Endothelium, Vascular, Enzyme Induction, Heart, Intestines, Kidney, Liver, Organ Specificity, Oxidoreductases, Polychlorinated Dibenzodioxins
Added March 21, 2013
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15 MeSH Terms
Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.
Lewis DF, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP
(1999) Toxicology 139: 53-79
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Bacterial Proteins, Cricetinae, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Flatfishes, Humans, Hydrogen Bonding, Mice, Mixed Function Oxygenases, Models, Molecular, Mutagenesis, Site-Directed, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Rabbits, Rats, Sequence Homology, Amino Acid, Species Specificity, Structure-Activity Relationship, Xenobiotics
Added May 26, 2014
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26 MeSH Terms