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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 2421 to 2428 of 2428

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Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells.
Rubin DH, Wetzel JD, Williams WV, Cohen JA, Dworkin C, Dermody TS
(1992) J Clin Invest 90: 2536-42
MeSH Terms: Animals, Antibodies, Monoclonal, Antigens, Viral, Capsid Proteins, Epitopes, Hemagglutination, In Vitro Techniques, L Cells (Cell Line), Leukemia, Erythroblastic, Acute, Mammalian orthoreovirus 3, Mice, Receptors, Virus, Tumor Cells, Cultured, Viral Proteins, Virus Replication
Show Abstract · Added December 10, 2013
The recognition of cellular receptors by the mammalian reoviruses is an important determinant of cell and tissue tropism exhibited by reovirus strains of different serotypes. To extend our knowledge of the role of reovirus-receptor interactions in reovirus tropism, we determined whether type 1 and type 3 reovirus strains can infect cells derived from erythrocyte precursors. We found that reovirus type 3 Dearing (T3D), but not type 1 Lang, can grow in murine erythroleukemia (MEL) cells. This difference in growth was investigated by using reassortant viruses and we found that the capacity of T3D to infect MEL cells is determined by the viral cell-attachment protein, sigma 1. In experiments using murine monoclonal antibodies (mAbs) that bind to different sigma 1 regions, we show that T3D binding to MEL cells is inhibited by a mAb that identifies a domain important for hemagglutination (HA). We also determined that type 3 strains that can infect murine L cells but do not produce HA do not infect MEL cells. These results suggest that type 3 reovirus binds to and infects erythrocyte precursor cells via a sigma 1 domain important for HA. Moreover, this study suggests that different domains of some viral cell-attachment proteins are used to initiate productive infections of different types of cells.
0 Communities
1 Members
0 Resources
15 MeSH Terms
Modification of histones immediately following synthesis.
Sealy L, Chalkley R
(1979) Arch Biochem Biophys 197: 78-82
MeSH Terms: Butyrates, Cells, Cultured, Chemical Phenomena, Chemistry, Histone Deacetylase Inhibitors, Histones
Added March 5, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
The relationship of heat killing and thermal radiosensitization to the duration of heating at 42 degrees C.
Freeman ML, Raaphorst GP, Dewey WC
(1979) Radiat Res 78: 172-5
MeSH Terms: Animals, Cell Survival, Cells, Cultured, Cricetinae, Cricetulus, Dose-Response Relationship, Radiation, Female, Hot Temperature, Ovary, Radiation Tolerance, Time Factors, X-Rays
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Changes in cellular heat and/or radiation sensitivity observed at various times after trypsinization and plating.
Raaphorst GP, Sapareto SA, Freeman ML, Dewey WC
(1979) Int J Radiat Biol Relat Stud Phys Chem Med 35: 193-7
MeSH Terms: Animals, Cell Survival, Cells, Cultured, Cricetinae, Cricetulus, Cytological Techniques, Hot Temperature, Radiation Tolerance, Time Factors, Trypsin, X-Rays
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes.
Helderman JH, Strom TB
(1979) J Biol Chem 254: 7203-7
MeSH Terms: Amanitins, Animals, Cells, Cultured, Cycloheximide, DNA, DNA Replication, Dactinomycin, Lectins, Lymphocyte Activation, Male, Protein Biosynthesis, RNA, Rats, Receptor, Insulin, T-Lymphocytes, Transcription, Genetic
Added April 21, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Epidermal growth factor stimulates secretion of human chorionic gonadotropin by cultured human choriocarcinoma cells.
Benveniste R, Speeg KV, Carpenter G, Cohen S, Lindner J, Rabinowitz D
(1978) J Clin Endocrinol Metab 46: 169-72
MeSH Terms: Cells, Cultured, Choriocarcinoma, Chorionic Gonadotropin, Culture Media, Epidermal Growth Factor, Female, Humans, Peptide Fragments, Peptides, Pregnancy, Uterine Neoplasms
Show Abstract · Added April 10, 2012
Epidermal growth factor (EGF) binds to JEG-3 cells, a tissue culture line of human choriocarcinoma. EGF also stimulates secretion of human chorionic gonadotropin (hCG) and to a lesser extent the secretion of free hCG-alpha.
0 Communities
1 Members
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11 MeSH Terms
Studies of the role of beta-adrenergic receptors in the activation of phosphorylase in rat hepatocytes by catecholamines.
Cherrington AD, Hundley RF, Dolgin S, Exton JH
(1977) J Cyclic Nucleotide Res 3: 263-73
MeSH Terms: Animals, Catecholamines, Cells, Cultured, Cyclic AMP, Drug Interactions, Enzyme Activation, Epinephrine, Glucagon, Isoproterenol, Liver, Phenoxybenzamine, Phenylephrine, Phosphorylases, Propranolol, Rats, Receptors, Adrenergic, Receptors, Adrenergic, beta, Time Factors
Added December 10, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
Effect of pH on hyperthermic cell survival.
Freeman ML, Dewey WC, Hopwood LE
(1977) J Natl Cancer Inst 58: 1837-9
MeSH Terms: Cell Survival, Cells, Cultured, Hot Temperature, Hydrogen-Ion Concentration, Hyperthermia, Induced, Neoplasms
Show Abstract · Added March 5, 2014
Chinese hamster ovary cells incubated with various concentrations of CO2, to obtain extracellular pH values in the range of 6.40-7.85, were heated at 45.5C for 5, 10, or 20 minutes. Thermal sensitivity increased sharply from pH 7.35 to 6.65 (i.e., survival decreased from 1 X 10(-2) to 3 X 10(-5) for 20 minutes of heating), but remained constant from pH 7.35 to 7.85. The enhanced thermal sensitivity at pH values below pth 7.35 suggested that tumors should be preferentially destroyed by heat relative to normal tissue, since reports indicated that tumors were more acidic than the surrounding normal tissue.
0 Communities
1 Members
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6 MeSH Terms