Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 201 to 207 of 207

Publication Record

Connections

The epidemiologic study of anatomic markers for increased risk of mammary cancer.
Dupont WD, Rogers LW, Vander Zwaag R, Page DL
(1980) Pathol Res Pract 166: 471-80
MeSH Terms: Breast Neoplasms, Female, Humans, Precancerous Conditions, Prospective Studies, Risk, Tennessee
Added March 21, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Are breast cysts a premalignant marker?
Page DL, Dupont WD
(1986) Eur J Cancer Clin Oncol 22: 635-6
MeSH Terms: Breast, Breast Neoplasms, Female, Fibrocystic Breast Disease, Humans, Precancerous Conditions, Prognosis, Risk
Added March 21, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Atypical hyperplastic lesions of the female breast. A long-term follow-up study.
Page DL, Dupont WD, Rogers LW, Rados MS
(1985) Cancer 55: 2698-708
MeSH Terms: Adult, Age Factors, Aged, Biopsy, Breast, Breast Neoplasms, Carcinoma in Situ, Carcinoma, Intraductal, Noninfiltrating, Female, Follow-Up Studies, Humans, Hyperplasia, Middle Aged, Precancerous Conditions, Prognosis, Risk, Time Factors
Show Abstract · Added March 21, 2014
A total of 10,542 breast biopsy specimens obtained between 1950 and 1968 were studied. Examples of atypical "ductal" (ADH) and atypical lobular hyperplasia (ALH), defined as having only some features of carcinoma in situ (CIS), were diagnosed in 3.6% of these specimens. In the same series, CIS was diagnosed in 1.7% of biopsy specimens excluding those with invasive cancer. The subsequent risk of invasive breast carcinoma after ALH or ADH was 4-5 times that of the general population. Follow-up was 90% successful and extended 17 years after biopsy. History of breast cancer in a mother, sister, or daughter doubled the risk of subsequent invasive carcinoma development (to 8 times for ALH and 10 times for ADH). The authors conclude that among the epithelial hyperplastic lesions of the human breast, a minority may be recognized by their resemblance to CIS which have a clinically significant elevation of subsequent breast cancer risk. This risk is one-half that of CIS.
0 Communities
1 Members
0 Resources
17 MeSH Terms
Premalignant conditions and markers of elevated risk in the breast and their management.
Page DL, Dupont WD
(1990) Surg Clin North Am 70: 831-51
MeSH Terms: Breast, Breast Diseases, Breast Neoplasms, Female, Humans, Hyperplasia, Precancerous Conditions, Risk Factors
Show Abstract · Added March 21, 2014
Most epithelial hyperplasias of the human breast indicate an increased likelihood of carcinoma development, and the majority are best understood as markers or indicators of higher risk. Prospective studies of women with hyperplasia biopsied in the premammographic era indicate that about 70 per cent of women had mild or no hyperplastic epithelial alterations and experienced no increase in the risk of subsequent carcinoma. About 25 per cent of women had well-developed hyperplastic changes associated with a risk 1.5 to 2.0 times that of the general population controlled for age and length of follow-up. Somewhat fewer than 5 per cent of women had specific patterns of atypical hyperplasia that approached the patterns of carcinoma in situ. The women with atypical hyperplasia had a risk of cancer four to five times that of the general population, or about half the risk associated with microscopic carcinoma in situ. Only ductal carcinoma in situ should be considered without question to be an intrinsically precancerous lesion because of its regular association with recurrence at the site of its initial diagnosis. No follow-up studies of comparable type involving women with mammographically detected lesions are as yet available. However, it is clear that the incidence of atypical hyperplasia is higher in mammographically directed biopsies. The principal therapeutic implication of these premalignant lesions is a need for intensified breast cancer surveillance and screening for these patients.
0 Communities
1 Members
0 Resources
8 MeSH Terms
American Cancer Society's Breast Cancer Detection Awareness Program: the 1988 middle Tennessee experience.
Kaufman AJ, Worrell J, Bain RS, Jones HW, Winfield AC
(1990) South Med J 83: 618-20
MeSH Terms: Adult, American Cancer Society, Attitude of Health Personnel, Biopsy, Breast, Breast Neoplasms, Evaluation Studies as Topic, Family Health, Female, Health Education, Hotlines, Humans, Mammography, Middle Aged, Pilot Projects, Tennessee, Time Factors, United States, Voluntary Health Agencies
Show Abstract · Added March 5, 2014
In an effort to augment public awareness of the benefits of screening mammography and to encourage the use of screening mammograms, the Tennessee Division of the American Cancer Society initiated the Breast Cancer Detection Awareness Program in March 1988. As a result of the initiative, 3,473 women telephoned for information, and 3,123 were found to be eligible for a screening mammogram. Of the 2,248 mammograms actually obtained, 1,764 (78%) were interpreted as normal, whereas 484 (22%) were classified as abnormal. Of the 484 women with abnormal mammograms, 277 (57%) were advised to have follow-up mammograms and 57 (12%) had excisional biopsy. The 55 biopsies reported showed benign changes in 83.6% and malignancy in 16.4%. Thus, nine malignancies were discovered from 2,248 screening mammograms (four malignancies per 1,000 mammograms). No malignancies were found in women between 35 and 39 years old.
0 Communities
1 Members
0 Resources
19 MeSH Terms
Anatomic markers of human premalignancy and risk of breast cancer.
Page DL, Dupont WD
(1990) Cancer 66: 1326-35
MeSH Terms: Breast, Breast Neoplasms, Female, Humans, Hyperplasia, Precancerous Conditions, Risk Factors
Show Abstract · Added March 21, 2014
Epithelial hyperplasia of the breast carries an increased likelihood of carcinoma development, with most lesions best understood as markers of higher risk. The indication of increased cancer risk for more worrisome or complex histologic patterns has been supported in many studies. About 25% of women who underwent biopsies in the premammographic era had well-developed hyperplastic changes associated with an elevated risk of 1.5 to 2.0 times that of the general population when age and length of time of follow-up were considered. Somewhat fewer than 5% of women had specific patterns of atypical hyperplasia (AH) that approached the criteria of carcinoma in situ (CIS). These women with AH had a risk of cancer four to five times that of the general population, or about one half the risk associated with microscopic CIS. Only ductal CIS should be considered without question to be an intrinsic precancerous lesion because of its regular association with recurrence at the site of its initial diagnosis. Further studies indicated an appreciable interaction between AH and other nonanatomic risk factors, particularly a family history of breast cancer. Also, lower dosage estrogen replacement after menopause does not affect risk in any histologically defined group. The atypical hyperplastic lesions are more common in women undergoing biopsies on the indication of mammographic calcifications than because of palpable masses. The primary therapeutic implications of these premalignant lesions are intensified breast cancer surveillance and screening for these patients.
0 Communities
1 Members
0 Resources
7 MeSH Terms
Indicators of increased breast cancer risk in humans.
Page DL, Dupont WD
(1992) J Cell Biochem Suppl 16G: 175-82
MeSH Terms: Biopsy, Breast, Breast Neoplasms, Cohort Studies, Female, Fibrocystic Breast Disease, Humans, Hyperplasia, Precancerous Conditions, Risk Factors, Time Factors
Show Abstract · Added March 21, 2014
Specific atypical histological patterns of epithelial hyperplasia (AH) indicate a medically relevant risk of breast cancer development in 5-10% of women with otherwise benign biopsies. This risk is about four times that of similar women, i.e., of the same age and at risk for the same length of time. These relative risks are not stable with time and fall 10-15 years after detection. Absolute risk for invasive breast cancer after AH is about 10% in 10-15 years after biopsy and is most certain for perimenopausal women. Proliferative disease without atypia predicts only a slight elevation of risk with a relative risk (RR) of 1.5 to 2 times that of the general population. There is such a strong interaction between family history and AH that it is relevant to consider women with atypical hyperplasia who have a positive family history (FH) of breast cancer separately from those who do not. The absolute risk of breast cancer development in women with AH without a FH was 8% in 10 years (RR about 4), whereas those with a positive family history experienced a risk of about 20% at 15 years (RR of about 10). This interaction of AH and FH has also been observed in other recent studies. Low replacement doses of conjugated estrogen after menopause do not further elevate risk beyond that identified by histology.(ABSTRACT TRUNCATED AT 250 WORDS)
0 Communities
1 Members
0 Resources
11 MeSH Terms